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HCV Protease

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Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

Products Related to HCV Protease(37)

  • GC25117 structure
    GC25117Azvudine
    CAS: 1011529-10-4
    Purity: >98%

    Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

  • GC32305 structure
    GC32305ACH-806 (GS9132)
    CAS: 870142-71-5
    Purity: >98%

    ACH-806 (GS9132) is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

  • GC37921 structure
    GC37921Voxilaprevir
    CAS: 1535212-07-7
    Purity: >99.50%

    A pan-genotypic HCV NS3/4A protease inhibitor

  • GC60947 structure
    GC60947Isoeuphorbetin
    CAS: 50886-61-8
    Purity: >98%

    Isoeuphorbetin, a dimeric coumarin isolated from Viola philippica, is a potent HCV protease inhibitor with an IC50 of 3.63 ?g/mL.

  • GC64016 structure
    GC64016Samatasvir
    CAS: 1312547-19-5
    Purity: >99.00%

    Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication.

  • GC64038 structure
    GC64038Simeprevir-13C,d3
    CAS: 923604-59-5
    Purity: >98%

    Simeprevir-13C,d3 (TMC435-13C,d3) is the 13C- and deuterium labeled Simeprevir.

  • GC64065 structure
    GC64065Coblopasvir
    CAS: 1312608-46-0
    Purity: >98%

    Coblopasvir (KW-136) is a pangenotypic non-structural protein 5A (NS5A) inhibitor.

  • GC64066 structure
    GC64066Coblopasvir dihydrochloride
    CAS: 1966138-53-3
    Purity: >98%

    Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor.

  • GC65345 structure
    GC65345BI 653048
    CAS: 1198784-72-3
    Purity: >98%

    BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM.

  • GC68453 structure
    GC68453ITMN 4077
    CAS: 790305-05-4
    Purity: >99.00%
  • GC71538 structure
    GC71538IDX184
    CAS: 1036915-08-8
    Purity: >99.00%

    IDX184 is a potent and orally bioavailable inhibitor of HCV replication.

  • GC71540 structure
    GC71540JTK-109
    CAS: 480462-62-2

    JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase.

  • GP10026 structure
    GP10026Hepatitis C virus
    Purity: >98%

    Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34.