Hedgehog

Ciliobrevin D is an inhibitor of dynein ATPase activity, preventing the cycling activity of the motor protein.

Cyclopamine-KAAD, a hedgehog signaling inhibitor, is a smoothened antagonist.

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened.

Smoothened (SMO) is a GPCR-like receptor which, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.

N-Palmitoyl-L-aspartate is a natural N-acylaspartate that inhibits Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog.

An inhibitor of hedgehog acyltransferase

Triparanol is a 24-dehydro cholesterol reductase (DHCR24) inhibitor (Ki = 0.523 μM), which is an enzyme involved in the biosynthesis of cholesterol.

A Hedgehog pathway inhibitor

An internal standard for the quantification of itraconazole

An inhibitor of 5-LO

A neuropeptide with diverse biological activities

An alkyne derivative of cholesterol for click chemistry

Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM.

3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4), a Vitamin D3 analogue, is a Hedgehog pathway inhibitor with an IC50 of 39.2 μM measured in U87MG cells.

1-Metladenosine-d3 drochloride is the drochloride salt form of deuterium labeled 1-Metladenosine.

SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway.

DS-1-38 is an EYA1 antagonist that blocks Sonic Hedgehog (SHH) signaling.

Itraconazole-d9 is the deuterium labeled Itraconazole.

S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM).