TAM Receptor
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TAM receptors (Tyro3, Axl, and Mer) belong to a family of receptor tyrosine kinases that have important effects on hemostasis and inflammation. TAM receptors affect cell proliferation, survival, adhesion, and migration. TAM receptors can be activated by the vitamin K-dependent proteins Gas6 and protein S. Protein S is more commonly known as an important cofactor for protein C as well as a direct inhibitor of multiple coagulation factors.
The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. TAM receptor signaling plays an especially important role in the engulfment and phagocytic clearance of apoptotic cells (ACs) and membranes in adult tissues.
Products Related to TAM Receptor(34)
- GC64071AZ14145845Purity: >98%
AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy.
- GC64385RU-302CAS: 1182129-77-6Purity: >98.00%
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth.
- GC69061EnapotamabCAS: 1912423-61-0Purity: >95.00%
Enapotamab is an AXL/UFO-related antibody that can be used to synthesize Bcl-xl inhibitor antibody activity molecule conjugates.
- GC73128PF-07265807CAS: 2412356-57-9Purity: >97.00%
PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively.
- GC74513BatiraxceptCAS: 2268717-61-7Purity: >96.00%
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc).
- GC74578MipasetamabCAS: 2361055-48-1Purity: >98.00%
Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor.
- GC81331LadarutatugCAS: 3075939-11-3Purity: >95.00%
Ladarutatug is a humanized monoclonal antibody targeting Tyrosine-protein kinase receptor UFO.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC64071 | AZ14145845 | - | >98% | |
AZ14145845 is a highly selective type I1/2 dual Mer/Axl kinase inhibitor with in vivo efficacy. | ||||
| GC64385 | RU-302 | 1182129-77-6 | >98.00% | |
RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth. | ||||
| GC67878 | TL4830031 | 2084107-15-1 | >98% | |
| GC68342 | Tilvestamab | 2226775-26-2 | >98% | |
| GC69061 | Enapotamab | 1912423-61-0 | >95.00% | |
Enapotamab is an AXL/UFO-related antibody that can be used to synthesize Bcl-xl inhibitor antibody activity molecule conjugates. | ||||
| GC73128 | PF-07265807 | 2412356-57-9 | >97.00% | |
PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. | ||||
| GC73370 | AXL-IN-13 | 2376928-82-2 | >98.00% | |
AXL-IN-13 is a potent and orally active AXL inhibitor (IC50: 1.6 nM, Kd: 0.26 nM). | ||||
| GC74513 | Batiraxcept | 2268717-61-7 | >96.00% | |
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). | ||||
| GC74578 | Mipasetamab | 2361055-48-1 | >98.00% | |
Mipasetamab is an IgG1κ antibody targeting to AXL, a tyrosine kinase receptor and an TAM Receptor. | ||||
| GC81331 | Ladarutatug | 3075939-11-3 | >95.00% | |
Ladarutatug is a humanized monoclonal antibody targeting Tyrosine-protein kinase receptor UFO. | ||||