GLPBio

Reversan

Catalog No.: GC12523Purity:>98.00%Synonyms: CBLC4H10
COASDSData Sheet
inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp)

Products are for research use only. Not for human use. We do not sell to patients.

Reversan
Cas No.: 313397-13-6
10mM (in 1mL DMSO)In Stock
$109.00
1
5mgIn Stock
$99.00
1
10mgIn Stock
$153.00
1
25mgIn Stock
$306.00
1
50mgIn Stock
$486.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor[1][2].

References:
[1]. Tivnan A, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.
[2]. Burkhart CA, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 Aug 15;69(16):6573-80.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
313397-13-6
Synonyms
CBLC4H10
Chemical Name
N-(3-morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
SMILES
O=C(C1=C(N=C(C2=CC=CC=C2)C=C3C4=CC=CC=C4)N3N=C1)NCCCN5CCOCC5
Molecular Formula
C26H27N5O2
Molecular Weight
441.52
Solubility
<11.04mg/ml in DMSO
Storage
Store at RT
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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