GLPBio

P-glycoprotein

Read More about this category

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

Products Related to P-glycoprotein(55)

  • GC10240 structure
    GC10240Atazanavir sulfate (BMS-232632-05)
    CAS: 229975-97-7
    Purity: >99.50%

    An inhibitor of HIV-1 protease

  • GC10391 structure
    GC10391Hypophyllanthin
    CAS: 33676-00-5
    Purity: >98.00%

    P-glycoprotein (P-gp) inhibitor

  • GC10928 structure
    GC10928Tariquidar methanesulfonate, hydrate
    CAS: 625375-83-9
    Purity: >98.00%

    A P-glycoprotein inhibitor

  • GC12523 structure
    GC12523Reversan
    CAS: 313397-13-6
    Purity: >98%

    inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp)

  • GC12945 structure
    GC12945Atazanavir
    CAS: 198904-31-3
    Purity: >98%

    An inhibitor of HIV-1 protease

  • GC12986 structure
    GC12986Risperidone
    CAS: 106266-06-2
    Purity: >98.00%

    Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Ki values of 4.8, 5.9nM for 5-HT2A and dopamine D2 receptor, respectively.

  • GC13375 structure
    GC13375Dofequidar fumarate
    CAS: 153653-30-6
    Purity: >98.00%

    MDR reversal agent

  • GC15570 structure
    GC15570Tariquidar
    CAS: 206873-63-4
    Purity: >98.50%

    Tariquidar is a potent and selective inhibitor of P-glycoprotein (P-gp) with a K D value of 5.1nM.

  • GC16609 structure
    GC16609LY335979 (Zosuquidar 3HCL)
    CAS: 167465-36-3
    Purity: >99.50%

    Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). LY335979 (Zosuquidar 3HCL) shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research.

  • GC16672 structure
    GC16672Zosuquidar
    CAS: 167354-41-8
    Purity: >98.00%

    Zosuquidar is a novel and potent P-glycoprotein (P-gp; K i =59nM) inhibitor and multidrug resistance (MDR) modulator.

  • GC16677 structure
    GC16677Valspodar
    CAS: 121584-18-7
    Purity: >98.00%

    Valspodar is a potent inhibitor of P-glycoprotein (P-gp) widely used in preclinical and clinical studies [1].

  • GC17163 structure
    GC17163Elacridar hydrochloride
    CAS: 143851-98-3
    Purity: >98.00%

    An inhibitor of MRP-1 and BCRP

  • GC17215 structure
    GC17215Elacridar
    CAS: 143664-11-3
    Purity: >98.00%

    An inhibitor of MRP-1 and BCRP

  • GC17718 structure
    GC17718Muscone
    CAS: 541-91-3
    Purity: >98.00%

    Muscone is a bioactive component of musk and acts as a potent anti-inflammatory agent, reducing proinflammatory cytokines and end-plate degeneration .

  • GC18460 structure
    GC18460Roquefortine C
    CAS: 58735-64-1
    Purity: >98%

    Roquefortine C is a mycotoxin that was first isolated from a strain of P.

  • GC18470 structure
    GC18470NSC 23925
    CAS: 858474-14-3
    Purity: >99.00%

    An inhibitor of P-gp

  • GC30033 structure
    GC30033Sinapine thiocyanate
    CAS: 7431-77-8
    Purity: >98.00%

    Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

  • GC30371 structure
    GC30371Alisol F
    CAS: 155521-45-2
    Purity: >98%

    Alisol F is a triterpene isolated from Alisma orientalis, has immunosuppressive and anti-virus functions.

  • GC31340 structure
    GC31340Encequidar (HM30181)
    CAS: 849675-66-7
    Purity: >98.00%

    Encequidar (HM30181) (HM30181; HM30181A) is a potent and selective inhibitor of P-glycoprotein.

  • GC32518 structure
    GC32518Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)
    CAS: 67812-42-4
    Purity: >98.00%

    Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) ((±)-Norverapamil hydrochloride ((±)-Norverapamil hydrochloride)), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

  • GC32593 structure
    GC32593Zamicastat (BIA 5-1058)
    CAS: 1080028-80-3
    Purity: >98.00%

    Zamicastat (BIA 5-1058) (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects.

  • GC32906 structure
    GC32906Sinapine
    CAS: 18696-26-9
    Purity: >99.50%

    Sinapine is an alkaloid isolated from seeds of the cruciferous species.

  • GC33151 structure
    GC33151Polyoxyethylene stearate (POES)
    CAS: 9004-99-3
    Purity: >98%

    Polyoxyethylene stearate (POES) (POES) is a non-ionic emulsifying agent.

  • GC33185 structure
    GC33185Encequidar mesylate (HM30181 (mesylate))
    CAS: 849675-87-2
    Purity: >98.00%

    HM30181 mesylate salt, a tetrazole derivative, is known as a P-glycoprotein inhibitor that has inhibitory activities on multidrug resistance in cancer cells.