IF 10
PMID: 36049144 ↗RGX-104 Hydrochloride
Catalog No.: GC19448Purity:>99.50%Synonyms: Abequolixron hydrochloride
RGX-104 Hydrochloride is an orally active liver X receptor (LXR) agonist that modulates innate immunity by activating the transcription of the apolipoprotein E (ApoE) gene.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 610318-03-1
10mM (in 1mL DMSO)In Stock
$150.00
1
2mgIn Stock
$54.00
1
5mgIn Stock
$108.00
1
10mgIn Stock
$171.00
1
25mgIn Stock
$342.00
1
50mgIn Stock
$540.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $150.00 | In Stock | 1 | |
| 2mg | $54.00 | In Stock | 1 | |
| 5mg | $108.00 | In Stock | 1 | |
| 10mg | $171.00 | In Stock | 1 | |
| 25mg | $342.00 | In Stock | 1 | |
| 50mg | $540.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
RGX-104 Hydrochloride is an orally active liver X receptor (LXR) agonist that modulates innate immunity by activating the transcription of the apolipoprotein E (ApoE) gene[1, 2]. Up-regulation of ApoE promotes the clearance of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), thereby reversing the immunosuppressive state of the tumor microenvironment and enhancing antitumor immune responses[3]. RGX-104 Hydrochloride also exhibits antitumor activity and induces cell pyroptosis[4, 5].
References:
[1] Tavazoie M F, Pollack I, Tanqueco R, et al. LXR/ApoE activation restricts innate immune suppression in cancer[J]. Cell, 2018, 172(4): 825-840. e18.
[2] Mita M, Mita A, Chmielowski B, et al. Abstract B001: A phase 1 trial of RGX-104, a first-in-class immunotherapy targeting the liver-X nuclear hormone receptor (LXR), in patients with refractory malignancies[J]. Molecular Cancer Therapeutics, 2018, 17(1_Supplement): B001-B001.
[3] Zhang J, Zhu X, Han L, et al. Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy[J]. Available at SSRN 4760648.
[4] Liang H, Shen X. LXR activation radiosensitizes non-small cell lung cancer by restricting myeloid-derived suppressor cells[J]. Biochemical and Biophysical Research Communications, 2020, 528(2): 330-335.
[5] Qiu W, Su W, Xu J, et al. Immunomodulatory‐Photodynamic Nanostimulators for Invoking Pyroptosis to Augment Tumor Immunotherapy[J]. Advanced Healthcare Materials, 2022, 11(21): 2201233.
Product Documents
Purity:>99.50%Appearance:A solid
Chemical Properties
CAS No.
610318-03-1
Synonyms
Abequolixron hydrochloride
SMILES
O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1.Cl
Molecular Formula
C34H34Cl2F3NO3
Molecular Weight
632.54
Solubility
DMSO : ≥ 130 mg/mL (218.09 mM);Water : < 0.1 mg/mL (insoluble)
Storage
4°C, protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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