GLPBio

FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

Products Related to FXR & LXR(82)

  • GC10760 structure
    GC10760XL335
    CAS: 629664-81-9
    Purity: >99.50%

    XL335 (FXR-450) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM.

  • GC10975 structure
    GC10975GW4064
    CAS: 278779-30-9
    Purity: >99.50%

    GW4064, as a synthetic FXR agonist with an EC 50 of 65nM, is used for the treatment of cholestatic liver diseases, metabolic syndrome and alcoholic liver disease.

  • GC17985 structure
    GC17985Chenodeoxycholic Acid
    CAS: 474-25-9
    Purity: >98.00%

    Chenodeoxycholic Acid is a natural primary bile acid with multiple biological activities.

  • GC19421 structure
    GC19421LY2562175
    CAS: 1103500-20-4
    Purity: >98.00%

    LY2562175 is a potent and selective? FXR ?agonist with an? EC 50 ?of 193 nM

  • GC10596 structure
    GC10596T0901317
    CAS: 293754-55-9
    Purity: >99.50%

    T0901317 is an orally active and highly selective LXR agonist with EC 50 =15nM for LXRα, and activates xenobiotic receptor pregnane X receptor (PXR) with EC 50 =23nM.

  • GC10755 structure
    GC10755Fexaramine
    CAS: 574013-66-4
    Purity: >99.00%

    farnesoid X receptor agonist

  • GC11700 structure
    GC1170025(S)-27-hydroxy Cholesterol
    CAS: 56845-83-1
    Purity: >98%

    liver x receptors (LXRα and LXRβ) activator

  • GC11885 structure
    GC11885Sevelamer HCl
    CAS: 152751-57-0
    Purity: >98.00%

    Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.

  • GC13431 structure
    GC1343124α-methyl Cholesterol
    CAS: 474-62-4
    Purity: >98.00%

    24α-methyl Cholesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

  • GC13680 structure
    GC13680SR-9243
    CAS: 1613028-81-1
    Purity: >99.50%

    inverse agonist of LXR

  • GC13887 structure
    GC1388725(R)-27-hydroxy Cholesterol
    CAS: 20380-11-4
    Purity: >98.00%

    25(R)-27-hydroxy Cholesterol is an agonist of liver X receptor (LXR) α and LXRβ, with the EC 50 of 0.085 and 0.071μM, respectively.

  • GC13954 structure
    GC13954LXR-623
    CAS: 875787-07-8
    Purity: >99.50%

    Liver X-receptor agonist

  • GC14158 structure
    GC14158Obeticholic Acid
    CAS: 459789-99-2
    Purity: >98.00%

    Obeticholic Acid (INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid) is a potent, selective and orally active farnesoid X receptor(FXR) agonist with an EC 50 of 99nM.

  • GC14638 structure
    GC14638SR9238
    CAS: 1416153-62-2
    Purity: >99.50%

    inverse agonist of the two LXR isoforms, LXRα and LXRβ

  • GC14972 structure
    GC1497222(R)-hydroxy Cholesterol
    CAS: 17954-98-2
    Purity: >98.00%

    22(R)-hydroxy Cholesterol is an endogenous agonist of the liver X receptor (LXR), with an EC 50 value of 325nM.

  • GC16964 structure
    GC16964GW3965
    CAS: 405911-09-3
    Purity: >98%

    An orally-active agonist of LXRα and LXRβ

  • GC17059 structure
    GC17059Acetyl Podocarpic Acid Anhydride
    CAS: 344327-48-6
    Purity: >98%

    LXR agonist

  • GC17658 structure
    GC17658Guggulsterone
    CAS: 95975-55-6
    Purity: >98.00%

    Guggulsterone is a plant sterol extracted from the resin of the plant Commiphora wightii. Guggulsterone can inhibit the growth of a wide variety of tumor cells and induce apoptosis through downregulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP, and survivin), modulation of cell cycle proteins (such as Cyclin D1 and c-Myc), activation of caspases, inhibition of Akt, and activation of JNK.

  • GC17696 structure
    GC17696GW3965 HCl
    CAS: 405911-17-3
    Purity: >99.50%

    GW3965 HCl is a selective, orally active, nonsteroidal agonist for liver X receptors (LXR).

  • GC17827 structure
    GC1782724(R)-hydroxy Cholesterol
    CAS: 27460-26-0
    Purity: >98.00%

    LXRα and LXRβ nuclear receptors activator

  • GC18076 structure
    GC1807624(S)-hydroxy Cholesterol
    CAS: 474-73-7
    Purity: >95.00%

    LXRα and LXRβ nuclear receptors activator

  • GC18212 structure
    GC18212Cilofexor
    CAS: 1418274-28-8
    Purity: >99.50%

    Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay).

  • GC18270 structure
    GC1827022(S)-hydroxy Cholesterol
    CAS: 22348-64-7
    Purity: >95.00%

    A synthetic oxysterol and LXR modulator

  • GC19363 structure
    GC19363Tropifexor
    CAS: 1383816-29-2
    Purity: >98.00%

    Tropifexor is a potent non-bile acid farnesoid X receptor (FXR) agonist with an EC 50 value of 0.2nM.