GLPBio

RN 1747

Catalog No.: GC15346Purity:>99.50%
COASDSData Sheet
TRPV4 agonist

Products are for research use only. Not for human use. We do not sell to patients.

RN 1747
Cas No.: 1024448-59-6
10mM (in 1mL DMSO)In Stock
$69.00
1
5mgIn Stock
$63.00
1
10mgIn Stock
$117.00
1
25mgIn Stock
$234.00
1
50mgIn Stock
$423.00
1
100mgIn Stock
$765.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

Description

RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1].

References:
[1]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1024448-59-6
Chemical Name
1-benzyl-4-((4-chloro-2-nitrophenyl)sulfonyl)piperazine
SMILES
ClC1=CC=C(C([N+]([O-])=O)=C1)S(=O)(N2CCN(CC3=CC=CC=C3)CC2)=O
Molecular Formula
C17H18ClN3O4S
Molecular Weight
395.87
Solubility
<39.59mg/ml in DMSO
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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