ROR

nuclear receptor RORα agonist

SR3335 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor alpha (RORα), with a K i value of 220nM.

RORγ-selective inverse agonist

agonist of the T cell-specific isoform of RORγ

inverse agonist of RORγ, potent and selective

inverse agonist of RORγ

RORα and γ inverse agonist

SR1078 is an agonist of the retinoic acid receptor-related orphan receptors (RORs) RORα and RORγ, with IC 50 values of 1-3μM.

GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA binding.

TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.

Vimirogant (VTP-43742) (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM).

GNE-0946 is a potent and selective RORγ( RORc) agonist with an EC50 value of 4 nM for HEK-293 cell.

AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ.

L 601920-0 (Methyl-3β-hydroxycholenate) is a ROR gamma modulator extracted from patent US20110263046 A1, in figure 2.

Cintirorgon (LYC-55716) (LYC-55716) is a first-in-class, selective and orally bioavailable RORγ agonist. Cintirorgon (LYC-55716) (LYC-55716) modulates gene expression of RORγ expressing T lymphocyte immune cells, resulting in enhanced effector function, as well as decreased immunosuppression, resulting in decreased tumor growth, and improved survival.

GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell.

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM.

A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release.

ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5.

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM.

TMP920 is a highly potent and selective RORγt antagonist.

Dehydrolithocholic acid (3-Oxo-5β-cholanoic acid; 3-oxoLCA; DLA) is a bile acid metabolite that inhibits T helper cell 17 (Th17) differentiation by interacting with retinoic acid receptor associated orphan receptor (RORγt).

An RORγt antagonist