RR-11a |
| Catalog No.GC33063 |
RR-11a is a synthetic enzyme inhibitor of Legumain (IC50=31-55 nM). RR-11a can be used for the research of cancer and acute myocardial infarction (AMI).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1361390-56-8
Sample solution is provided at 25 µL, 10mM.
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RR-11a is a synthetic enzyme inhibitor of Legumain.
Legumain-targeted RR-11a-coupled nanoparticles reveal high ligand-receptor affinity, enhance solid-tumor penetration and uptake by tumor cells[1].
Treatment of tumor-bearing mice with RR-11a-coupled NPs encapsulating doxorubicin results in improved tumor selectivity and drug sensitivity, leading to complete inhibition of tumor growth[1].
[1]. Liao D, et al. Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity. Nanomedicine. 2011 Dec;7(6):665-73.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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