(S)-Ketoprofen (Synonyms: (S)-2-(3-benzoylphenyl)Propionic Acid,Dexketoprofen) |
Catalog No.GC15977 |
COX-1 and COX-2 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 22161-81-5
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(S)-Ketoprofen, a dual COX1/2 inhibitor, can be used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains. Ketoprofen is photolabile and undergoes degradation when irradiated by sunlight to induce various skin diseases [1].
In vitro: The combination of UVB irradiation with ketoprofen dose-dependently induced the cytotoxicity and suppressed DNA synthesis in HaCaT cells. UVB-irradiated KP inhibited the cell growth and induced G2/M cell cycle arrest by regulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. The DAPI staining results has revealed that KP accentuated the apoptotic response to UVB radiation in HaCaT cells [1].
In vivo: In a placebo-controlled, double-blind study in the rhesus monkeys Macaca mulatta with periodontal disease, administeration of KP at 1% level in suitable topical vehicles to the gingiva once daily at a standard dose of 1.8 ml per monkey for 6 months effectively inhibited GCF-LTB4 and GCF-PGE2 and positively altered alveolar bone activity [2]. Ketoprofen at a dose of 3.63 mg/kg bwt (phenylbutazone equimolar dose) showed significant analgesic effects and reduced hoof pain and lameness to a greater extent [3]. Treatment with Ketoprofen (40 and 80 mg/kg diet) greatly reduced the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice [4].
References:
[1]. Liu S, Mizu H, Yamauchi H. Molecular response to phototoxic stress of UVB-irradiated ketoprofen through arresting cell cycle in G2/M phase and inducing apoptosis[J]. Biochemical and biophysical research communications, 2007, 364(3): 650-655.
[2]. Li K L, Vogel R, Jeffcoat M K, et al. The effect of ketoprofen creams on periodontal disease in rhesus monkeys[J]. Journal of periodontal research, 1996, 31(8): 525-532.
[3]. Owens J G, Kamerling S G, Stanton S R, et al. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse[J]. Equine Veterinary Journal, 1995, 27(4): 296-300.
[4]. Hawk E T, Kelloff G J, McCormick D L. Differential activity of aspirin, ketoprofen and sulindac as cancer chemopreventive agents in the mouse urinary bladder[J]. Carcinogenesis, 1996, 17(5): 1435-1438.
Cas No. | 22161-81-5 | SDF | |
Synonyms | (S)-2-(3-benzoylphenyl)Propionic Acid,Dexketoprofen | ||
Chemical Name | (S)-3-benzoyl-α-methyl-benzeneacetic acid | ||
Canonical SMILES | O=C(C1=CC=CC([C@H](C)C(O)=O)=C1)C2=CC=CC=C2 | ||
Formula | C16H14O3 | M.Wt | 254.3 |
Solubility | ≥ 10.6mg/mL in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.9324 mL | 19.6618 mL | 39.3236 mL |
5 mM | 0.7865 mL | 3.9324 mL | 7.8647 mL |
10 mM | 0.3932 mL | 1.9662 mL | 3.9324 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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