GLPBio

(S,R,S)-AHPC-Me-CO-C4-COOH

Catalog No.: GC80912Purity:>99.50%
COASDSData Sheet
(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12.

Products are for research use only. Not for human use. We do not sell to patients.

(S,R,S)-AHPC-Me-CO-C4-COOH
Cas No.: 2349429-73-6
10mM (in 1mL DMSO)In Stock
$69.00
1
50mgIn Stock
$63.00
1
100mgIn Stock
$117.00
1
250mgIn Stock
$270.00
1
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Citations

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

(S,R,S)-AHPC-Me-CO-C4-COOH is a conjugate of the E3 ligase VHL ligand and a linker, which can be used to synthesize PROTAC ERα Degrader-12. PROTAC ERα Degrader-12 is a potent and highly selective ERα PROTAC degrader [1].

References:
[1]. Wang Y, et al. Targeted Degradation of the Estrogen Receptor α through Unconventional Coactivator Binding Site (CBS). J Med Chem. 2025 Jul 10;68(13):13640-13660.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2349429-73-6
Molecular Formula
C29H40N4O6S
Molecular Weight
572.72
Solubility
DMSO: 50 mg/mL (87.30 mM; Need ultrasonic)
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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