E3 Ligase Ligand-Linker Conjugate

E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Products Related to E3 Ligase Ligand-Linker Conjugate(201)

GC30050 E3 ligase Ligand-Linker Conjugates 17
CAS: 1950635-16-1
Purity: >99.00%
E3 ligase Ligand-Linker Conjugates 17 (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC30064 E3 ligase Ligand-Linker Conjugates 16
CAS: 1799711-25-3
Purity: >99.50%
E3 ligase Ligand-Linker Conjugates 16 (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC30071 E3 ligase Ligand-Linker Conjugates 4
CAS: 1797406-81-5
Purity: >98.50%
E3 ligase Ligand-Linker Conjugates 4 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC30105 E3 ligase Ligand-Linker Conjugates 18
CAS: 2098488-36-7
Purity: >98.50%
E3 ligase Ligand-Linker Conjugates 18 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC32761 E3 ligase Ligand-Linker Conjugates 14
CAS: 1957236-21-3
Purity: >99.50%
E3 ligase Ligand-Linker Conjugates 14 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
GC32779 E3 Ligase Ligand-Linker Conjugates 1
CAS: 2097938-44-6
Purity: >99.00%
E3 Ligase Ligand-Linker Conjugates 1 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32813 E3 ligase Ligand-Linker Conjugates 5
CAS: 2097971-11-2
Purity: >98.00%
E3 ligase Ligand-Linker Conjugates 5 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC32839 E3 ligase Ligand-Linker Conjugates 6
CAS: 2097973-72-1
Purity: >98%
E3 ligase Ligand-Linker Conjugates 6 (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
GC32866 E3 ligase Ligand-Linker Conjugates 7
CAS: 2064292-52-8
Purity: >99.00%
E3 ligase Ligand-Linker Conjugates 7 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC32871 E3 Ligase Ligand-Linker Conjugates 2
CAS: 1818885-63-0
Purity: >98.00%
E3 Ligase Ligand-Linker Conjugates 2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32888 E3 ligase Ligand-Linker Conjugates 13
CAS: 2010159-45-0
Purity: >99.50%
E3 ligase Ligand-Linker Conjugates 13 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology.
GC32903 E3 Ligase Ligand-Linker Conjugates 22
CAS: 2225940-52-1
Purity: >98%
E3 Ligase Ligand-Linker Conjugates 22 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32986 E3 ligase Ligand-Linker Conjugates 11
CAS: 1835705-61-7
Purity: >98%
E3 ligase Ligand-Linker Conjugates 11 is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. E3 ligase Ligand-Linker Conjugates 11 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
GC32994 E3 ligase Ligand-Linker Conjugates 7 Free Base
CAS: 2010159-57-4
Purity: >98%
E3 ligase Ligand-Linker Conjugates 7 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC33000 E3 ligase Ligand-Linker Conjugates 12
CAS: 1797406-80-4
Purity: >98%
E3 ligase Ligand-Linker Conjugates 12 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC33103 E3 Ligase Ligand-Linker Conjugates 21
CAS: 1957236-20-2
Purity: >98%
E3 Ligase Ligand-Linker Conjugates 21 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
GC33110 E3 ligase Ligand-Linker Conjugates 3
CAS: 2101200-09-1
Purity: >98.00%
E3 ligase Ligand-Linker Conjugates 3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.
GC33111 E3 ligase Ligand-Linker Conjugates 6 Free Base
CAS: 2010159-60-9
Purity: >98%
E3 ligase Ligand-Linker Conjugates 6 Free Base (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
GC33113 E3 ligase Ligand-Linker Conjugates 5 Free Base
CAS: 2010159-56-3
Purity: >98%
E3 ligase Ligand-Linker Conjugates 5 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC33129 Thalidomide-O-amido-C4-NH2
CAS: 1799711-24-2
Purity: >98%
Thalidomide-O-amido-C4-NH2 is an E3 ubiquitin ligase ligand-linker conjugate (CRBN ligand-linker conjugate) that can be covalently linked to a target protein (POI) ligand to assemble a heterobifunctional PROTAC (Proteolysis Targeting Chimera) molecule, triggering ubiquitination of the target protein and directing protein to proteasomal degradation.
GC33390 E3 Ligase Ligand-Linker Conjugates 20
CAS: 1950635-15-0
Purity: >98%
E3 Ligase Ligand-Linker Conjugates 20 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
GC33473 E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
CAS: 1950635-14-9
Purity: >99.50%
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
GC33847 Thalidomide-O-amido-PEG2-C2-NH2 TFA
CAS: 1957235-75-4
Purity: >99.50%
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
GC34334 E3 Ligase Ligand-Linker Conjugates 23 TFA
Purity: >98%

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC30050	E3 ligase Ligand-Linker Conjugates 17	1950635-16-1	>99.00%
GC30050	E3 ligase Ligand-Linker Conjugates 17 (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC30064	E3 ligase Ligand-Linker Conjugates 16	1799711-25-3	>99.50%
GC30064	E3 ligase Ligand-Linker Conjugates 16 (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC30071	E3 ligase Ligand-Linker Conjugates 4	1797406-81-5	>98.50%
GC30071	E3 ligase Ligand-Linker Conjugates 4 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC30105	E3 ligase Ligand-Linker Conjugates 18	2098488-36-7	>98.50%
GC30105	E3 ligase Ligand-Linker Conjugates 18 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
GC32761	E3 ligase Ligand-Linker Conjugates 14	1957236-21-3	>99.50%
GC32761	E3 ligase Ligand-Linker Conjugates 14 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
GC32779	E3 Ligase Ligand-Linker Conjugates 1	2097938-44-6	>99.00%
GC32779	E3 Ligase Ligand-Linker Conjugates 1 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32813	E3 ligase Ligand-Linker Conjugates 5	2097971-11-2	>98.00%
GC32813	E3 ligase Ligand-Linker Conjugates 5 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC32839	E3 ligase Ligand-Linker Conjugates 6	2097973-72-1	>98%
GC32839	E3 ligase Ligand-Linker Conjugates 6 (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
GC32866	E3 ligase Ligand-Linker Conjugates 7	2064292-52-8	>99.00%
GC32866	E3 ligase Ligand-Linker Conjugates 7 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC32871	E3 Ligase Ligand-Linker Conjugates 2	1818885-63-0	>98.00%
GC32871	E3 Ligase Ligand-Linker Conjugates 2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32888	E3 ligase Ligand-Linker Conjugates 13	2010159-45-0	>99.50%
GC32888	E3 ligase Ligand-Linker Conjugates 13 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology.
GC32903	E3 Ligase Ligand-Linker Conjugates 22	2225940-52-1	>98%
GC32903	E3 Ligase Ligand-Linker Conjugates 22 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
GC32986	E3 ligase Ligand-Linker Conjugates 11	1835705-61-7	>98%
GC32986	E3 ligase Ligand-Linker Conjugates 11 is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. E3 ligase Ligand-Linker Conjugates 11 is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
GC32994	E3 ligase Ligand-Linker Conjugates 7 Free Base	2010159-57-4	>98%
GC32994	E3 ligase Ligand-Linker Conjugates 7 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
GC33000	E3 ligase Ligand-Linker Conjugates 12	1797406-80-4	>98%
GC33000	E3 ligase Ligand-Linker Conjugates 12 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC33103	E3 Ligase Ligand-Linker Conjugates 21	1957236-20-2	>98%
GC33103	E3 Ligase Ligand-Linker Conjugates 21 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
GC33110	E3 ligase Ligand-Linker Conjugates 3	2101200-09-1	>98.00%
GC33110	E3 ligase Ligand-Linker Conjugates 3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology.
GC33111	E3 ligase Ligand-Linker Conjugates 6 Free Base	2010159-60-9	>98%
GC33111	E3 ligase Ligand-Linker Conjugates 6 Free Base (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
GC33113	E3 ligase Ligand-Linker Conjugates 5 Free Base	2010159-56-3	>98%
GC33113	E3 ligase Ligand-Linker Conjugates 5 Free Base is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
GC33129	Thalidomide-O-amido-C4-NH2	1799711-24-2	>98%
GC33129	Thalidomide-O-amido-C4-NH2 is an E3 ubiquitin ligase ligand-linker conjugate (CRBN ligand-linker conjugate) that can be covalently linked to a target protein (POI) ligand to assemble a heterobifunctional PROTAC (Proteolysis Targeting Chimera) molecule, triggering ubiquitination of the target protein and directing protein to proteasomal degradation.
GC33390	E3 Ligase Ligand-Linker Conjugates 20	1950635-15-0	>98%
GC33390	E3 Ligase Ligand-Linker Conjugates 20 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
GC33473	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate	1950635-14-9	>99.50%
GC33473	E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
GC33847	Thalidomide-O-amido-PEG2-C2-NH2 TFA	1957235-75-4	>99.50%
GC33847	Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
GC34334	E3 Ligase Ligand-Linker Conjugates 23 TFA	-	>98%