Schisantherin D is a lignan. Schisantherin D can be isolated from Kadsura interior. Schisantherin D downregulates the expression of ETBR and inhibits the secretion of ECM and ET-1. Schisantherin D alleviates EtOH + ET-1-induced hepatocyte cytotoxicity. Schisantherin D potently inhibits HIV replication in cells [1] [2].
In Vitro, Schisantherin D (50 μM; 2 h) attenuates EtOH + ET-1-induced cytotoxicity and enhances cell viability in HL-7702 hepatocytes[1]. Schisantherin D inhibits the secretion of Col-I, Col-III, FN and ET-1 by LX-2 hepatic stellate cells stimulated with EtOH + ET-1[1]. Schisantherin D (0.8-100 µg/mL; 4 days) potently inhibits HIV replication in H9 lymphocytes, with an EC50 of 0.5 µg/mL, a therapeutic index of 50.6, and a cytotoxic IC50 of 25.3 µg/mL[2].
References:
[1]. Xu JB, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4 -induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020;258:112813.
[2]. Chen DF, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996;59(11):1066-1068.
In Vitro, Schisantherin D (50 μM; 2 h) attenuates EtOH + ET-1-induced cytotoxicity and enhances cell viability in HL-7702 hepatocytes[1]. Schisantherin D inhibits the secretion of Col-I, Col-III, FN and ET-1 by LX-2 hepatic stellate cells stimulated with EtOH + ET-1[1]. Schisantherin D (0.8-100 µg/mL; 4 days) potently inhibits HIV replication in H9 lymphocytes, with an EC50 of 0.5 µg/mL, a therapeutic index of 50.6, and a cytotoxic IC50 of 25.3 µg/mL[2].
References:
[1]. Xu JB, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4 -induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020;258:112813.
[2]. Chen DF, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996;59(11):1066-1068.