GLPBio

Endothelin Receptor

Endothelin receptors are members of rhodopsin-like g-protein coupled receptor (GPCRA) with 4 types (ETA, ETB1, ETB2 and ETC), which mediate various physiological processes including vasoconstriction, vasodilation, and neurotransmission etc.

Products Related to Endothelin Receptor(53)

  • GC11465 structure
    GC11465Bosentan Hydrate
    CAS: 157212-55-0
    Purity: >99.50%

    endothelin receptor antagonist

  • GC16269 structure
    GC16269Bosentan
    CAS: 147536-97-8
    Purity: >99.50%

    Endothelin receptor antagonist

  • GC16862 structure
    GC16862Zibotentan (ZD4054)
    CAS: 186497-07-4
    Purity: >98.00%

    Zibotentan (ZD4054) (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM.

  • GC17785 structure
    GC17785Macitentan
    CAS: 441798-33-0
    Purity: >99.00%

    Endothelin (ET)(A) and ET(B) receptor antagonist

  • GA20810 structure
    GA20810Big Endothelin-3 (1-41) amide (human)
    CAS: 133551-97-0
    Purity: >95.00%

    Big Endothelin-3 (1-41) amide (human) is a precursor molecule of the Endothelin (ET)-3 peptide composing of 41 amino acids.

  • GC11314 structure
    GC11314Atrial natriuretic factor (1-28) (rat)
    CAS: 88898-17-3
    Purity: >98%

    Atrial natriuretic factor (1-28) (rat) is a major circulating form of ANP in rats, potently inhibits Angiotensin II (Ang II)-stimulated endothelin-1 secretion in a concentration-dependent manner.

  • GC11405 structure
    GC11405Avosentan
    CAS: 290815-26-8
    Purity: >98.00%
  • GC11783 structure
    GC11783Atrasentan hydrochloride
    CAS: 195733-43-8
    Purity: >99.50%
  • GC12231 structure
    GC12231Sulfisoxazole
    CAS: 127-69-5
    Purity: >99.50%

    selective ETA endothelin receptor antagonist

  • GC13175 structure
    GC13175Sarafotoxin S6a
    CAS: 126738-34-9
    Purity: >98%

    Endothelin receptor agonist

  • GC13236 structure
    GC13236ACT-132577
    CAS: 1103522-45-7
    Purity: >98.00%

    ACT-132577 (ACT-132577) is the major and pharmacologically active metabolite of Macitentan.

  • GC13924 structure
    GC13924Endothelin 3 (human, rat)
    CAS: 117399-93-6
    Purity: >95.00%

    Endothelin 3 (human, rat) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

  • GC14678 structure
    GC14678Sarafotoxin S6b
    CAS: 116303-65-2
    Purity: >98%

    non-selective endothelin receptor agonist

  • GC15246 structure
    GC15246IRL-2500
    CAS: 169545-27-1
    Purity: >99.00%

    endothelin receptor antagonist

  • GC15887 structure
    GC15887BQ-123
    CAS: 136553-81-6
    Purity: >98.00%

    BQ-123 is a highly potent and selective endothelin A (ETA) receptor antagonist with an IC 50 value of 7.3nM and a K i value of 25nM.

  • GC15916 structure
    GC15916BQ-788 sodium salt
    CAS: 156161-89-6
    Purity: >98.00%

    BQ-788 sodium salt is a selective nonpeptide endothelin type B (ETB) receptor antagonist with an IC 50 of 1.2nM. BQ-788 sodium salt can specifically bind to ETB receptors, blocking the interaction between endothelin and its receptors, thereby inhibiting endothelin-mediated effects such as vasoconstriction and cell proliferation.

  • GC17184 structure
    GC17184Ambrisentan
    CAS: 177036-94-1
    Purity: >99.50%

    Ambrisentan is an orally active, highly selective antagonist of endothelin receptor ETA-selective antagonist, with an IC 50 value of 0.6nM.

  • GC17769 structure
    GC17769Sitaxentan sodium
    CAS: 210421-74-2
    Purity: >98.00%

    Sitaxentan sodium is a selective endothelin A receptor (ETA) antagonist (IC 50 = 1.4 nM; K i = 0.43nM).

  • GC18501 structure
    GC18501Kendomycin
    CAS: 183202-73-5
    Purity: >98%

    Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM).

  • GC30485 structure
    GC30485Endothelin 1 swine, human
    CAS: 117399-94-7
    Purity: >98.00%

    Endothelin 1 (swine, human) is a 21aa peptide vasoconstrictor and agonist of endothelin (ET) receptors ETA and ETB (IC50s = 0.15 and 0.12 nM, respectively).

  • GC30577 structure
    GC30577Endothelin Mordulator 1
    CAS: 349453-49-2
    Purity: >98%

    Endothelin Mordulator 1 is a endothelin receptor modulator, used for the research of endothelin-mediated disorders.

  • GC30937 structure
    GC30937IRL-1620
    CAS: 142569-99-1
    Purity: 98.93%

    IRL-1620 is a potent and selective endothelin B receptor (ETB) agonist (K i =16pM).

  • GC30942 structure
    GC30942Tezosentan (RO 610612)
    CAS: 180384-57-0
    Purity: >98%

    Tezosentan (RO 610612) (RO 610612) is an endothelin (ET) receptor antagonist, with pA2s of 9.5, 7.7 for ETA and ETB receptors, respectively.

  • GC32479 structure
    GC32479Sparsentan (RE-021)
    CAS: 254740-64-2
    Purity: >98.50%

    Sparsentan (RE-021) (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively.