SGK

SGK (serine/threonine-protein kinase) is important in activating certain potassium, sodium, and chloride channels.

Products Related to SGK(11)

GC15441 GSK 650394
CAS: 890842-28-1
Purity: >99.50%
GSK 650394 is an effective selective inhibitor of serum and glucocorticoid-regulated kinase-1 (SGK1), with IC 50 values of 62nM and 103nM for SGK1 and SGK2, respectively.
GC17986 EMD638683
CAS: 1181770-72-8
Purity: >99.50%
EMD638683 is a selective serum and glucocorticoid-induced kinase 1 (SGK1) inhibitor (IC 50 =3μM).
GC30673 SGK1-IN-1
CAS: 1279829-87-6
Purity: >98.50%
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
GC35977 EMD638683 R-Form
CAS: 1184940-47-3
Purity: >99.50%
EMD638683 R-Form is the R-form of EMD638683.
GC35978 EMD638683 S-Form
CAS: 1184940-46-2
Purity: >99.50%
EMD638683 (S-Form) is a SGK1 inhibitor with an IC50 of >300 nM.
GC38755 CKI-7
CAS: 120615-25-0
Purity: >99.00%
CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
GC39426 PROTAC SGK3 degrader-1
CAS: 2381320-35-8
Purity: >99.00%
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate).
GC62431 SGK1-IN-2
CAS: 1426214-64-3
Purity: >98.00%
SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration.
GC64706 SGK1-IN-4
CAS: 1628048-93-0
Purity: >99.50%
SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor.
GC73088 SGK1-IN-3 hydrochloride
Purity: >96.00%
SGK1-IN-3 drochloride (compound 3a) is a potent and orally active inhibitor of SGK1.
GC73111 HaloPROTAC-E
CAS: 2365478-58-4
Purity: >99.00%
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC15441	GSK 650394	890842-28-1	>99.50%
GC15441	GSK 650394 is an effective selective inhibitor of serum and glucocorticoid-regulated kinase-1 (SGK1), with IC 50 values of 62nM and 103nM for SGK1 and SGK2, respectively.
GC17986	EMD638683	1181770-72-8	>99.50%
GC17986	EMD638683 is a selective serum and glucocorticoid-induced kinase 1 (SGK1) inhibitor (IC 50 =3μM).
GC30673	SGK1-IN-1	1279829-87-6	>98.50%
GC30673	SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.
GC35977	EMD638683 R-Form	1184940-47-3	>99.50%
GC35977	EMD638683 R-Form is the R-form of EMD638683.
GC35978	EMD638683 S-Form	1184940-46-2	>99.50%
GC35978	EMD638683 (S-Form) is a SGK1 inhibitor with an IC50 of >300 nM.
GC38755	CKI-7	120615-25-0	>99.00%
GC38755	CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
GC39426	PROTAC SGK3 degrader-1	2381320-35-8	>99.00%
GC39426	PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate).
GC62431	SGK1-IN-2	1426214-64-3	>98.00%
GC62431	SGK1-IN-2 (14h) is a selective SGK1 (serum and glucocorticoid regulated kinase 1) inhibitor, with an IC50 of 5 nM at 10 μM ATP concentration.
GC64706	SGK1-IN-4	1628048-93-0	>99.50%
GC64706	SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor.
GC73088	SGK1-IN-3 hydrochloride	-	>96.00%
GC73088	SGK1-IN-3 drochloride (compound 3a) is a potent and orally active inhibitor of SGK1.
GC73111	HaloPROTAC-E	2365478-58-4	>99.00%
GC73111	HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM