SIKs

SIKs (salt-inducible kinases) are serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis and tumor suppression etc.

Products Related to SIKs(12)

GC11719 HG-9-91-01
CAS: 1456858-58-4
Purity: >99.00%
HG-9-91-01 is a salt-inducible kinases (SIK) inhibitor, inhibited SIK1, SIK2, SIK3 with IC50 values of 0.92nM, 6.5nM and 19.4nM, respectively.
GC31645 YKL-05-099
CAS: 1936529-65-5
Purity: >99.50%
YKL-05-099 is a highly selective small molecule inhibitor of salt-inducible kinases (SIK1: IC 50 = 10nM; SIK2: IC 50 = 40nM; SIK3: IC 50 = 20nM).
GC33070 ARN-3236
CAS: 1613710-01-2
Purity: >99.50%
ARN-3236 is a selective salt-inducible kinase 2 (SIK2) inhibitor with an IC 50 of less than 1nM. ARN-3236 also inhibits the activity of SIK1 (IC 50 <21.63nM) and SIK3 (IC 50 <6.63nM).
GC37951 YKL-06-061
CAS: 2172617-15-9
Purity: >99.00%
YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
GC39148 Pterosin B
CAS: 34175-96-7
Purity: >99.00%
Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling.
GC39195 YKL-06-062
CAS: 2172617-16-0
Purity: >98.00%
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively.
GC62142 WH-4-025
CAS: 1876463-35-2
Purity: >98.50%
WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2).
GC62657 MRIA9
CAS: 2750707-05-0
Purity: >98.00%
MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.
GC69169 GLPG3970
CAS: 2403733-82-2
Purity: >98%
GLPG3970 (compound 88) is a novel SIK2/SIK3 inhibitor. GLPG3970 can be used for research on inflammation and autoimmune diseases.
GC72915 (R)-MRT199665
Purity: >98.00%
(R)-MRT199665 is an isomer of MRT199665.
GC73750 GLPG3312
CAS: 2340388-72-7
Purity: >98.00%
GLPG3312 (Compound 28) is a selective pan-SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively.
GC79425 SK-124
CAS: 2760404-50-8
Purity: >95.00%
SK-124 is an orally active salt-inducible kinase ( SIK ) inhibitor with an IC 50 of 230 nM against SIK1, 4.1 nM against SIK2, and 21 nM against SIK3, exhibiting excellent kinome selectivity [1] [2] [4] . SK-124 blocks SIK-mediated CRTC2 phosphorylation, promotes CRTC2 nuclear translocation, and regulates vitamin D metabolism by upregulating renal Cyp27b1 and downregulating Cyp24a1 [1] [4] . SK-124 upregulates the expression of bone-related genes, increases serum Ca 2+, 1,25-vitamin D and intact FGF23 levels, and suppresses endogenous PTH levels [1] [2] [3] [4] . SK-124 can be used in studies related to osteoporosis, male osteoporosis, and chronic kidney disease-mineral and bone disorder [2] [3] [4] .

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC11719	HG-9-91-01	1456858-58-4	>99.00%
GC11719	HG-9-91-01 is a salt-inducible kinases (SIK) inhibitor, inhibited SIK1, SIK2, SIK3 with IC50 values of 0.92nM, 6.5nM and 19.4nM, respectively.
GC31645	YKL-05-099	1936529-65-5	>99.50%
GC31645	YKL-05-099 is a highly selective small molecule inhibitor of salt-inducible kinases (SIK1: IC 50 = 10nM; SIK2: IC 50 = 40nM; SIK3: IC 50 = 20nM).
GC33070	ARN-3236	1613710-01-2	>99.50%
GC33070	ARN-3236 is a selective salt-inducible kinase 2 (SIK2) inhibitor with an IC 50 of less than 1nM. ARN-3236 also inhibits the activity of SIK1 (IC 50 <21.63nM) and SIK3 (IC 50 <6.63nM).
GC37951	YKL-06-061	2172617-15-9	>99.00%
GC37951	YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.
GC39148	Pterosin B	34175-96-7	>99.00%
GC39148	Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling.
GC39195	YKL-06-062	2172617-16-0	>98.00%
GC39195	YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM, respectively.
GC62142	WH-4-025	1876463-35-2	>98.50%
GC62142	WH-4-025 is a Salt-inducible kinase (SIK) inhibitor (WO2016023014 A2).
GC62657	MRIA9	2750707-05-0	>98.00%
GC62657	MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively.
GC69169	GLPG3970	2403733-82-2	>98%
GC69169	GLPG3970 (compound 88) is a novel SIK2/SIK3 inhibitor. GLPG3970 can be used for research on inflammation and autoimmune diseases.
GC72915	(R)-MRT199665	-	>98.00%
GC72915	(R)-MRT199665 is an isomer of MRT199665.
GC73750	GLPG3312	2340388-72-7	>98.00%
GC73750	GLPG3312 (Compound 28) is a selective pan-SIK inhibitor with IC50 values of 2.0 nM, 0.7 nM and 0.6 nM for SIK1, SIK2 and SIK3, respectively.
GC79425	SK-124	2760404-50-8	>95.00%
GC79425	SK-124 is an orally active salt-inducible kinase ( SIK ) inhibitor with an IC 50 of 230 nM against SIK1, 4.1 nM against SIK2, and 21 nM against SIK3, exhibiting excellent kinome selectivity [1] [2] [4] . SK-124 blocks SIK-mediated CRTC2 phosphorylation, promotes CRTC2 nuclear translocation, and regulates vitamin D metabolism by upregulating renal Cyp27b1 and downregulating Cyp24a1 [1] [4] . SK-124 upregulates the expression of bone-related genes, increases serum Ca 2+, 1,25-vitamin D and intact FGF23 levels, and suppresses endogenous PTH levels [1] [2] [3] [4] . SK-124 can be used in studies related to osteoporosis, male osteoporosis, and chronic kidney disease-mineral and bone disorder [2] [3] [4] .