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SJB3-019A

Catalog No.GC13401

Usp1 inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

SJB3-019A Chemical Structure

Cas No.: 2070015-29-9

Size Price Stock Qty
10mM (in 1mL DMSO)
$96.00
In stock
2mg
$72.00
In stock
5mg
$95.00
In stock
10mg
$170.00
In stock
50mg
$595.00
In stock
100mg
$1,146.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

SJB3-019A is a potent and novel inhibitor of USP1 with IC50 value of 0.0781 μM [1].

Ubiquitin-specific protease 1 (USP1) is a deubiquitinating (DUB) enzyme and removes polyubiquitin chains from the DNA binding 1 (ID1) protein, which plays an important role in the proliferation and progression of cancers, such as leukemia [1].

SJB3-019A is a potent and novel USP1 inhibitor. In K562 cells, SJB3-019A exhibited 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity. In HeLa cells, SJB3-019A increased the levels of Ub-PCNA and Ub-FANCD2 and reduced the homologous recombination activity [1].

Reference:
[1].  Mistry H, Hsieh G, Buhrlage SJ, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther, 2013, 12(12): 2651-2662.

Chemical Properties

Cas No. 2070015-29-9 SDF
Chemical Name 2-(pyridin-3-yl)naphtho[2,3-d]oxazole-4,9-dione
Canonical SMILES O=C(C1=C2OC(C3=CN=CC=C3)=N1)C4=CC=CC=C4C2=O
Formula C16H8N2O3 M.Wt 276.25
Solubility ≥ 10.85mg/mL in DMSO with gentle warming Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.6199 mL 18.0995 mL 36.1991 mL
5 mM 0.724 mL 3.6199 mL 7.2398 mL
10 mM 0.362 mL 1.81 mL 3.6199 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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