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DUB

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Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).

Products Related to DUB(16)

  • GC10356 structure
    GC10356DUBs-IN-3
    CAS: 924296-17-3
    Purity: >99.00%

    DUBs-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8.

  • GC10970 structure
    GC10970WP1130
    CAS: 856243-80-6
    Purity: >99.50%

    WP1130 (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. WP1130 has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.

  • GC12622 structure
    GC12622HBX 41108
    CAS: 924296-39-9
    Purity: >98.00%

    HBX 41108 is a potent inhibitor of USP7 with IC 50 value of 424nM . HBX 41108 is shown to affect USP7-mediated p53 deubiquitinating in vitro and in cells.

  • GC13401 structure
    GC13401SJB3-019A
    CAS: 2070015-29-9
    Purity: >97.00%

    SJB3-019A is a novel and potent USP1 inhibitor, exhibiting an IC₅₀ value of 0.0781μM in K562 cells.

  • GC13892 structure
    GC13892C527
    CAS: 192718-06-2
    Purity: >99.50%

    Inhibitor of USP1/USF1 complex

  • GC17125 structure
    GC17125DUBs-IN-2
    CAS: 924296-19-5
    Purity: >98.00%

    DUBs-IN-2 is a highly selective and membrane-permeable inhibitor for USP8 with IC 50 value of 0.28μM.

  • GC17635 structure
    GC17635ML-323
    CAS: 1572414-83-5
    Purity: >99.50%

    ML-323 is a highly reversible and highly effective selective inhibitor of USP1-UAF1 with an IC 50 value of 76nM.

  • GC10379 structure
    GC10379P 22077
    CAS: 1247819-59-5
    Purity: >98.00%
  • GC10510 structure
    GC10510LDN 57444
    CAS: 668467-91-2
    Purity: >98%

    LDN 57444 is a small molecular inhibitor that can block UCHL1 deubiquitinase activity (K i =0.40μM; IC 50 =0.88μM), with an IC 50 value of 25μM for inhibiting UCHL3.

  • GC10601 structure
    GC10601Ubiquitin Isopeptidase Inhibitor I
    CAS: 108477-18-5
    Purity: >97.00%

    Ubiquitin Isopeptidase Inhibitor I (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

  • GC12067 structure
    GC12067P005091
    CAS: 882257-11-6
    Purity: >99.50%

    P005091 is a potent and selective ubiquitin-specific proteinase 7 (USP7) inhibitor with an EC50 value of 4.2 μM.

  • GC12475 structure
    GC12475NSC 632839 hydrochloride
    CAS: 157654-67-6
    Purity: >98.50%

    A deubiquitylase and deSUMOylase inhibitor

  • GC14797 structure
    GC14797IU1
    CAS: 314245-33-5
    Purity: >98.00%

    IU1 is a cytopermeable, reversible selective inhibitor of proteasome with an IC 50 of 4.7μM for USP14.

  • GC17269 structure
    GC17269Vialinin A
    CAS: 858134-23-3
    Purity: >98.00%

    A natural immunosuppressant from fungi

  • GC17698 structure
    GC17698SJB2-043
    CAS: 63388-44-3
    Purity: >99.00%

    An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PL pro

  • GC17912 structure
    GC17912C598-0466
    Purity: >98%

    USP7 inhibitor