3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research.
3,4-Dimethoxychalcone (30 μM, 8 h) induces autophagic flux in HepG2 cells and U2OS cells[1].3,4-Dimethoxychalcone (30 μM, 6 h) stimulates the translocation of TFEB and TFE3 to the nucleus in U2OS cells[1].
3,4-Dimethoxychalcone (230 mg/kg for intraperitoneal injection) induces the nuclear translocation of TFEB and TFE3 of liver and heart tissues in Female C57/BL6 mice[1].
References:
[1]. Okolo EN, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021 Nov 5;11(1):21781.
[2]. Chen G, et al. 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Mol Med. 2019 Nov 7;11(11):e10469.