Aminopterin (Synonyms: 4-amino Folic Acid, 4-amino PGA, APGA, NSC 739) |
| Catalog No.GC42789 |
La aminopterina (Ácido 4-aminofÓlico), el derivado 4-amino del Ácido fÓlico, es un antagonista del Ácido fÓlico.
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Cas No.: 54-62-6
Sample solution is provided at 25 µL, 10mM.
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Aminopterin is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate is now more commonly used due to a more favorable therapeutic index. Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.
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