BI-7273 acid, BI-7273 derivative, is a BRD9 PROTAC ligand. BI-7273 acid can be conjugated with E3 ligase Ligand Thalidomide and linker to synthesize BRD9 PROTAC degrader dBRD 9-A [1].
In Vitro, PROTACs consists of two distinct ligands linked by a linker: one is a ligand for an E3 ubiquitin ligase, and the other is a ligand for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References:
[1]. Brien GL, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018;7:e41305. Published 2018 Nov 15.
In Vitro, PROTACs consists of two distinct ligands linked by a linker: one is a ligand for an E3 ubiquitin ligase, and the other is a ligand for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References:
[1]. Brien GL, et al. Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma. Elife. 2018;7:e41305. Published 2018 Nov 15.