Chymase-IN-1 |
| Catalog No.GC31930 |
La quimasa-IN-1 es un inhibidor no peptÍdico potente, selectivo y activo por vÍa oral de la quimasa de los mastocitos humanos con una IC50 de 29 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 862090-74-2
Sample solution is provided at 25 µL, 10mM.
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Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].
[1]. Greco MN, et al. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
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