GLPBio

Compstatin

Catalog No.: GC15251Purity:>98%
COASDSData Sheet
La compstatina, un péptido cÍclico de 13 residuos, es un potente inhibidor del sistema del complemento C3 con especificidad de especie.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

Compstatin
Cas No.: 206645-99-0
1mgIn Stock
$81.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

Actualmente no hay citas disponibles para este producto. A continuación se muestran publicaciones seleccionadas que citan productos GlpBio.
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

Compstatin is a 13-residue cyclic peptide and a potent inhibitor of the complement system, and has species specificity.

Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans); Compstatin inhibits only the activation of primates' complement system[1].

Compstatin (21 mg/kg) produces complete inhibition when given as a combination of bolus injection and infusion. Compstatin completely inhibits in vivo heparin/protamine-induced complement activation without adverse effects on heart rate or systemic arterial, central venous, and pulmonary arterial pressures[1]. Pig xenografts survival is significantlylonger in the Compstatin perfused group than in the control group. At rejection the biopsy samples obtained from kidneysperfused with Compstatin show less deposition of C3 and fibrin than do the control kidneys[2].

References:
[1]. Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21.
[2]. Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65.

Protocolo (Protocol)

Animal experiment:

Compstatin-perfused circuit: pig xenografts are perfused with human blood containing Compstatin (final conc. 0.088 mg/mL). Control group: pig kidneys perfused with human blood and control agent. The total fluid volume, protein concentration and amount of blood are equal in both the Compstatin and control perfusion circuits, and the perfusion is performed in both circuits simultaneously with pooled blood from the same two donors.

References:

[1]. Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96(3):212-21.
[2]. Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6(1):52-65.

Propiedades químicas (Chemical Properties)

N.º CAS
206645-99-0
Nombre químico
2-((4R,5Z,7S,8Z,10S,11Z,13S,14Z,17Z,19S,20Z,22S,23Z,25S,26Z,28S,29Z,31S,32Z,34R)-10,13-bis((1H-imidazol-5-yl)methyl)-19-((1H-indol-3-yl)methyl)-34-((Z)-((2S,3S)-2-amino-1-hydroxy-3-methylpentylidene)amino)-4-((Z)-(((2S,3R)-1,3-dihydroxy-1-iminobutan-2-yl)
SMILES
CC[C@]([C@@](N)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/1)([H])CCCNC(N)=N)([H])CC2=CN=CN2)([H])CC3=CN=CN3)([H])CC4=CNC5=CC=CC=C45)([H])CC(O)=O)([H])
Fórmula molecular
C66H99N23O17S2
Peso molecular
1550.77
Solubilidad
Soluble to 2 mg/ml in sterile water
Almacenamiento
Store at -20°C
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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