Dapagliflozin keto impurity (Oxo-dapagliflozin) is an oxo metabolite and related impurity of Dapagliflozin. Dapagliflozin keto impurity can be characterized by 1 H NMR, 13 C NMR and HRMS, and can be used in studies related to Dapagliflozin impurities and metabolites [1].
In Vitro, Dapagliflozin keto impurity (Oxo-dapagliflozin) is an off-white amorphous solid, which is prepared via multi-step chemical synthesis using methoxyoxo-dapagliflozin as the starting material with a yield of 80%. Its structure is confirmed by NMR and HRMS[1]. Dapagliflozin keto impurity is obtained by hydrolyzing tetraacetyl oxo dapagliflozin with LiOH·H2O. The reaction proceeds at 20-30°C for 16 h, with a yield of 84%[1].
References:
[1]. Karumanchi K, et al. Synthesis of metabolites of dapagliflozin: an SGLT2 inhibitor. J Chem Sci. 2020;132:42.
In Vitro, Dapagliflozin keto impurity (Oxo-dapagliflozin) is an off-white amorphous solid, which is prepared via multi-step chemical synthesis using methoxyoxo-dapagliflozin as the starting material with a yield of 80%. Its structure is confirmed by NMR and HRMS[1]. Dapagliflozin keto impurity is obtained by hydrolyzing tetraacetyl oxo dapagliflozin with LiOH·H2O. The reaction proceeds at 20-30°C for 16 h, with a yield of 84%[1].
References:
[1]. Karumanchi K, et al. Synthesis of metabolites of dapagliflozin: an SGLT2 inhibitor. J Chem Sci. 2020;132:42.