GLPBio

DPP-4

Read More about this category

Dipeptidyl peptidase-4 (DPP-4), originally identified in 1966 as a dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide, is a membrane-associated peptidase that selectively cleaves the N-terminal penultimate proline or alanine amino acids. The most common substrates of DPP-4 include glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), peptide YY, neuropeptide, chemokine ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) and substance P. DPP-4, as a type II cell surface protein and a soluble form, has been found to be widely distributed in organs (such as the bone marrow, the lung, spleen, liver, pancreas, kidney and intestines) and body fluids (such as serum/plasma, cerebrospinal fluid, synovial fluid and semen). Besides its peptidase activity, DPP-4 has been found to be associated with immune stimulation, extracellular matrix degradation, lipid accumulation and resistance to anticancer agents.

Products Related to DPP-4(18)

  • GC12895 structure
    GC12895Saxagliptin
    CAS: 361442-04-8
    Purity: >99.50%

    Saxagliptin es un inhibidor muy potente de la dipeptidyl peptidase-4 (DPP-4) que regula la glucemia al inhibir la enzima DPP-4, aumentando así los niveles de peptido similar al glucagón endógeno 1 (GLP-1) y al polipéptido insulinotrópico dependiente de la glucosa (GIP)

  • GC10104 structure
    GC10104Glimepiride
    CAS: 93479-97-1
    Purity: >98.00%

    Glimepiride es una sulfonilurea de segunda generación que estimula las células β pancreáticas para liberar insulina. Glimepiride se utiliza para el tratamiento de la diabetes mellitus tipo 2 en monoterapia, así como en combinación con metformina o insulina

  • GC10298 structure
    GC10298Sitagliptin phosphate monohydrate
    CAS: 654671-77-9
    Purity: >99.50%
  • GC10802 structure
    GC10802K 579
    CAS: 440100-64-1
    Purity: >98%
  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    Purity: >98.00%

    La sitagliptina (fosfato) (fosfato MK-0431) es un potente inhibidor de DPP4 con una IC50 de 19 nM en extractos de células Caco-2.

  • GC12603 structure
    GC12603DPPI 1c hydrochloride
    CAS: 866396-34-1
    Purity: >98%

    A DPP-4 inhibitor

  • GC13949 structure
    GC13949Alogliptin Benzoate
    CAS: 850649-62-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC14126 structure
    GC14126NVP DPP 728 dihydrochloride
    CAS: 247016-69-9
    Purity: >98%
  • GC14201 structure
    GC14201PK 44 phosphate
    CAS: 1017682-65-3
    Purity: >98%

    DPP-IV inhibitor

  • GC14786 structure
    GC14786P32/98 (hemifumarate)
    CAS: 251572-86-8
    Purity: >98%

    P32/98 (hemifumarato) es un potente inhibidor de la dipeptidil peptidasa IV con un valor Ki de 130 nM.

  • GC14827 structure
    GC14827Linagliptin (BI-1356)
    CAS: 668270-12-0
    Purity: >99.50%

    A potent DPP-4 inhibitor

  • GC15130 structure
    GC15130Alogliptin (SYR-322)
    CAS: 850649-61-5
    Purity: >99.00%
  • GC15576 structure
    GC15576Teneligliptin hydrobromide
    CAS: 906093-29-6
    Purity: >99.50%

    A DPP-4 inhibitor

  • GC16613 structure
    GC16613Trelagliptin
    CAS: 865759-25-7
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC16733 structure
    GC16733Vildagliptin (LAF-237)
    CAS: 274901-16-5
    Purity: >98.00%

    A DPP-4 inhibitor

  • GC17012 structure
    GC17012MK3102
    CAS: 1226781-44-7
    Purity: >99.00%

    MK3102(Omarigliptina)es una nuevo inhibidor de la dipeptidil peptidasa-4(DPP-4)que se administra una vez a la semana(IC50: 2.2 nM) desarrollado para el tratamiento de la diabetes tipo 2.

  • GC17479 structure
    GC17479Trelagliptin succinate
    CAS: 1029877-94-8
    Purity: >99.50%

    A DDP-4 inhibitor

  • GC10018 structure
    GC10018Talabostat mesylate
    CAS: 150080-09-4
    Purity: >99.00%

    Talabostat mesylate es un inhibidor activo por v&iacute;a oral y no selectivo de la dipeptidil peptidasa IV (DPP-IV) (IC 50 < 4 nM; K i = 0.18 nM) y el primer inhibidor cl&iacute;nico de la prote&iacute;na de activaci&oacute;n de fibroblastos (FAP) (IC 50 = 560 nM), inhibiendo DPP 8/9 (IC 50 = 4/11 nM; K i = 1.5/0.76 nM), prolil endopeptidasa (QPP) (IC50= 310 nM), DPP2,y otras enzimas de la familia DASH.