GLPBio

DUB

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Deubiquitinating enzymes (DUBs), belonging to the superfamily of proteases, are a group of enzymes that catalyze the cleavage of ubiquitin from ubiquitin-linked molecules after the terminal carbonyl of the last residue of ubiquitin (Gly76). Based on the mechanism of catalysis, DUBs is divided into two classes, cysteine proteases, which interact with substrates through the thiol group of a cysteine in the active site, and metalloproteases, which form a noncovalent intermediate with the substrate through a Zn2+ bound polarized water molecule. The cysteine protease DUBs have different Ub-protease domains and hence are further divided into four subclasses, ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), Otubain protease (OTU) and Machado-Joseph disease protease (MJD); while all metalloprotease DUBs have one Ub protease domain called JAMM (JAB1/MPN/Mov34 metalloenzyme).

Products Related to DUB(16)

  • GC10356 structure
    GC10356DUBs-IN-3
    CAS: 924296-17-3
    Purity: >99.00%

    DUBs-IN-3 es un potente inhibidor de la enzima deubiquitinasa (USP) extraÍdo del compuesto de referencia 22c con una IC50 de 0,56 μM para USP8.

  • GC10970 structure
    GC10970WP1130
    CAS: 856243-80-6
    Purity: >99.50%

    WP1130 (WP1130) es un inhibidor de la deubiquitinasa permeable a las células (DUB), que inhibe directamente la actividad DUB de USP9x, USP5, USP14 y UCH37. Se ha demostrado que WP1130 regula a la baja las proteÍnas antiapoptÓticas Bcr-Abl y JAK2.

  • GC12622 structure
    GC12622HBX 41108
    CAS: 924296-39-9
    Purity: >98.00%

    HBX 41108 es un potente inhibidor de la USP7 con un valor de IC 50 de 424nM

  • GC13401 structure
    GC13401SJB3-019A
    CAS: 2070015-29-9
    Purity: >97.00%

    SJB3-019A es un inhibidor de USP1 potente y novedoso, 5 veces mÁs potente que SJB2-043 para promover la degradaciÓn de ID1 y la citotoxicidad en células K562 con IC50 de 0,0781 μM.

  • GC13892 structure
    GC13892C527
    CAS: 192718-06-2
    Purity: >99.50%

    C527 es un inhibidor de la enzima pan DUB, con una alta potencia para el complejo USP1/UAF1 (IC50=0,88 μM).

  • GC17125 structure
    GC17125DUBs-IN-2
    CAS: 924296-19-5
    Purity: >98.00%

    DUBs-IN-2 es un inhibidor selectivo y permeable a las membranas para la USP8, con un valor de IC 50 de 0.28μM

  • GC17635 structure
    GC17635ML-323
    CAS: 1572414-83-5
    Purity: >99.50%

    ML-323 es un inhibidor selectivo altamente reversible y altamente efectivo de USP1-UAF1 con un valor de IC 50 de 76nM.

  • GC10379 structure
    GC10379P 22077
    CAS: 1247819-59-5
    Purity: >98.00%
  • GC10510 structure
    GC10510LDN 57444
    CAS: 668467-91-2
    Purity: >98%

    LDN 57444 is a small molecular inhibitor that can block UCHL1 deubiquitinase activity (K i =0.40μM; IC 50 =0.88μM), with an IC 50 value of 25μM for inhibiting UCHL3.

  • GC10601 structure
    GC10601Ubiquitin Isopeptidase Inhibitor I
    CAS: 108477-18-5
    Purity: >97.00%

    El inhibidor de ubiquitina isopeptidasa I (NSC 144303) es una caspasa independiente del apoptosoma y un activador de la apoptosis con valores IC50 de 1,76 y 1,6 μM en células E1A y E1A/C9DN, respectivamente.

  • GC12067 structure
    GC12067P005091
    CAS: 882257-11-6
    Purity: >99.50%

    P005091 es un inhibidor potente selectivo de la proteinasa 7 específica de la ubiquitina (USP7) con un valor de EC50 de 4,2 μM.

  • GC12475 structure
    GC12475NSC 632839 hydrochloride
    CAS: 157654-67-6
    Purity: >98.50%

    A deubiquitylase and deSUMOylase inhibitor

  • GC14797 structure
    GC14797IU1
    CAS: 314245-33-5
    Purity: >98.00%

    IU1 es un inhibidor selectivo citopermeable y reversible del proteasoma con un IC 50 de 4.7μM para USP14.

  • GC17269 structure
    GC17269Vialinin A
    CAS: 858134-23-3
    Purity: >98.00%

    A natural immunosuppressant from fungi

  • GC17698 structure
    GC17698SJB2-043
    CAS: 63388-44-3
    Purity: >99.00%

    An inhibitor of the USP1-UAF1 complex and SARS-CoV-2 PL pro

  • GC17912 structure
    GC17912C598-0466
    Purity: >98%

    USP7 inhibitor