GLPBio

FLY26

Catalog No.: GC83039Purity:>99.50%
COASDSData Sheet
FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

FLY26
10mM (in 1mL DMSO)In Stock
$173.00
1
5mgIn Stock
$158.00
1
10mgIn Stock
$252.00
1
25mgIn Stock
$461.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

Actualmente no hay citas disponibles para este producto. A continuación se muestran publicaciones seleccionadas que citan productos GlpBio.
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

FLY26 is a selective partial GluN2B antagonist with an IC50 value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury [1].

References:
[1]. Fan Y, et al. A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats. Bioorg Chem. 2025 Apr 30;161:108547.

Documentos del producto (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

Fórmula molecular
C22H23N5O3
Peso molecular
405.45
Solubilidad
DMSO: 125 mg/mL (308.30 mM; Need ultrasonic)
Almacenamiento
Store at 4°C, sealed storage, away from moisture
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

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