H-Glu(Tyr-OH)-OH |
Catalog No.GA22366
One-Click Copy Product Info
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H-Glu(Tyr-OH)-OH es un dipéptido compuesto de ácido glutámico (Glu) y tirosina (Tyr). Su nombre químico es L-glutamyl-L-tyrosine, con la fórmula molecular C₁₄H₁₈N₂O₆ y un peso modecular de aproximadamente 310.3. H-Glu(Tyr-OH)-OH es un inhibidor competitivo de la dipeptidil peptidasa-IV (DPP-IV) (IC₅₀ = 6.77 mM) y puede tener potencial para el tratamiento de la diabetes tipo II .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 7432-23-7
Sample solution is provided at 25 µL, 10mM.
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H-Glu(Tyr-OH)-OH es un dipéptido compuesto de ácido glutámico (Glu) y tirosina (Tyr). Su nombre químico es L-glutamyl-L-tyrosine, con la fórmula molecular C₁₄H₁₈N₂O₆ y un peso modecular de aproximadamente 310.3. H-Glu(Tyr-OH)-OH es un inhibidor competitivo de la dipeptidil peptidasa-IV (DPP-IV) (IC₅₀ = 6.77 mM) y puede tener potencial para el tratamiento de la diabetes tipo II [1]. La porción de tirosina de H-Glu(Tyr-OH)-OH contiene un grupo hidroxilo fenólico, que puede conferir propiedades antioxidantes, lo que le permite reaccionar con radicales libres y, por lo tanto, reducir el daño oxidativo[2]. El ácido glutámico y la tirosina son precursores importantes de los neurotransmisores, y los productos de hidrólisis de H-Glu(Tyr-OH)-OH pueden estar onvolucrados en la transmisión y modulación de las señales nerviosas[3]. Algunos estudios sugieren que en la enfermedad de Alzheimer y la enfermedad de Parkinson, el metabolismo de la glutamina y la tirosina es anormal, y los niveles de H-Glu(Tyr-OH)-OH y sus metabolitos relacionados también pueden cambiar [4].
References:
[1] Juan Yang, Dongxiao Sun-Waterhouse, Chun Cui, et al. γ‐Glu‐Met synthesised using a bacterial glutaminase as a potential inhibitor of dipeptidyl peptidase IV[J]. International Journal of Food Science & Technology, 2018, 53(5): 1166-1175.
[2] Jeffrey RF, MacDonald TM, Lee MR. A comparison of the renal actions of gamma-L-glutamyl-L-dopa and gamma-L-glutamyl-L-tyrosine in normal man. Clin Sci (Lond). 1988 Jan;74(1):37-40.
[3] Nemeroff CB. The role of neuropeptides in the pathophysiology of affective disorders. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:6A-7A.
[4] Liu S, Zhong H, Zhu J, et al. Identification of blood metabolites associated with risk of Alzheimer's disease by integrating genomics and metabolomics data. Mol Psychiatry. 2024 Apr;29(4):1153-1162.
| Cas No. | 7432-23-7 | SDF | |
| Formula | C14H18N2O6 | M.Wt | 310.31 |
| Solubility | Soluble in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2226 mL | 16.1129 mL | 32.2258 mL |
| 5 mM | 644.5 μL | 3.2226 mL | 6.4452 mL |
| 10 mM | 322.3 μL | 1.6113 mL | 3.2226 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)