α-Bisabolol (Synonyms: DL-α-Bisabolol) |
Catalog No.GC35305 |
α- El bisabolol es un alcohol sesquiterpénico no tÓxico presente en aceite esencial natural, con actividad anticancerÍgena. α-El bisabolol ejerce un efecto anticancerÍgeno selectivo en las células de NSCLC A549 (IC50=15 μM) mediante la inducciÓn de la detenciÓn del ciclo celular, la apoptosis mitocondrial y la inhibiciÓn de las vÍas de seÑalizaciÓn de PI3K/Akt. α-Bisabolol también induce fuertemente la apoptosis en las células de glioma.
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Cas No.: 515-69-5
Sample solution is provided at 25 µL, 10mM.
alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells[1][2].
[1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412. [2]. Cavalieri E, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004 Mar 12;315(3):589-94.
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