Ophiopogonin D' is a steroidal saponin and a SIRT1 activator. Ophiopogonin D' can also regulate the activities of transporters OATP1B1 and OATP1B3. Ophiopogonin D' exhibits certain toxicity to tumor cells. Ophiopogonin D' can be used in tumor research [1] [2] [3].
In Vitro, Ophiopogonin D' (48 h) has IC50 values of 3.09 μM and 3.63 μM for MG-63 and SNU387 cells, respectively[1]. Ophiopogonin D' (0-64 μM; 5-10 min) promotes the uptake of Rosuvastatin and Atorvastatin in a concentration-dependent manner in OATP1B1-HEK293T cells, with EC50 values of 4.62 μM and 3.68 μM, respectively[3]. Ophiopogonin D' (0-64 μM; 5 min) increases the uptake of Rosuvastatin (EC50: 14.95 μM) and reduces the uptake of Telmisartan in a concentration-dependent manner (IC50: 4.44 μM) in OATP1B3-HEK293T cells[3].
References:
[1]. Wang L, et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.
[2]. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.
[3]. Chen L, et al. Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis. Xenobiotica. 2019 Oct;49(10):1221-1228.
In Vitro, Ophiopogonin D' (48 h) has IC50 values of 3.09 μM and 3.63 μM for MG-63 and SNU387 cells, respectively[1]. Ophiopogonin D' (0-64 μM; 5-10 min) promotes the uptake of Rosuvastatin and Atorvastatin in a concentration-dependent manner in OATP1B1-HEK293T cells, with EC50 values of 4.62 μM and 3.68 μM, respectively[3]. Ophiopogonin D' (0-64 μM; 5 min) increases the uptake of Rosuvastatin (EC50: 14.95 μM) and reduces the uptake of Telmisartan in a concentration-dependent manner (IC50: 4.44 μM) in OATP1B3-HEK293T cells[3].
References:
[1]. Wang L, et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.
[2]. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.
[3]. Chen L, et al. Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis. Xenobiotica. 2019 Oct;49(10):1221-1228.