Lemairamin (Synonyms: Wgx-50) |
Catalog No.GC79513
One-Click Copy Product Info
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Lemairamin (Wgx-50) is a hydroxylamine compound.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 29946-61-0
Sample solution is provided at 25 µL, 10mM.
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In Vivo, Lemairamin (10 μL/L; immersion; 6-18 h) exerts dose-time-dependent anti-inflammatory effects in a zebrafish DSS-induced inflammatory bowel disease model, reducing neutrophil recruitment and pro-inflammatory cytokine expression, preserving intestinal morphology, and inhibiting Akt pathway activation, with maximal effects observed at 12 hours of treatment[1]. Lemairamin (1-300 mg/kg; s.c.) dose-dependently inhibits formalin-induced tonic pain in male Swiss mice with an Emax of 66.7% inhibition and an ED50 of 11.1 mg/kg, via activation of α7nAChRs[2]. Lemairamin (1-300 mg/kg; s.c.; single administration) dose-dependently inhibits formalin-induced tonic pain in adult Wistar rats with an Emax of 45.9% inhibition and an ED50 of 21.9 mg/kg[2]. Lemairamin (10-300 μg; i.t.; single administration) dose-dependently reduces mechanical allodynia in L5/L6 spinal nerve ligated Wistar rats with an Emax of 60.4% MPE and an ED50 of 83.9 μg, via α7nAChR activation and subsequent stimulation of spinal IL-10 and β-endorphin expression[2].
In Vitro, Lemairamin (10 μM; 2 h) stimulates the expression of IL-10 and POMC in primary rat spinal cord microglia[2].
References:
[1]. Zhang L, et al. Lemairamin (Wgx-50) Attenuates DSS-Induced Intestinal Inflammation in Zebrafish. Int J Mol Sci. 2024;25(17):9510. Published 2024 Sep 1.
[2]. Wang ZY, et al. Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors. Biochem Biophys Res Commun. 2020;525(4):1087-1094.
| Cas No. | 29946-61-0 | SDF | |
| Sinónimos | Wgx-50 | ||
| Formula | C19H21NO3 | M.Wt | 311.37 |
| Solubility | DMSO: 100 mg/mL (321.16 mM; Need ultrasonic) | Storage | Store at 4°C, protect from light |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.2116 mL | 16.0581 mL | 32.1161 mL |
| 5 mM | 642.3 μL | 3.2116 mL | 6.4232 mL |
| 10 mM | 321.2 μL | 1.6058 mL | 3.2116 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)