NV03 |
| Catalog No.GC64772 |
NV03 es un antagonista potente y selectivo de la interacciÓn UHRF1 (similar a la ubiquitina con PHD y dominios de dedo RING 1)-H3K9me3 mediante la uniÓn al dominio tudor en tÁndem UHRF1, con una Kd de 2,4 μM. NV03 tiene actividad anticancerÍgena.
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Cas No.: 2448341-58-8
Sample solution is provided at 25 µL, 10mM.
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NV03 is a potent and selective antagonist of UHRF1 (Ubiquitin-like with PHD and RING finger domains 1)- H3K9me3 interaction by binding to UHRF1 tandem tudor domain, with a Kd of 2.4 μM. NV03 has anticancer activity[1].
[1]. Senisterra G, et al. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain. SLAS Discov. 2018 Oct;23(9):930-940.
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