Prednisone-d7 is intended for use as an internal standard for the quantification of prednisone by GC- or LC-MS. Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.1 It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.2 Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.3 Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.
1.Brownie, A.C.The metabolism of adrenal cortical steroidsThe Adrenal Gland2209-225(1992) 2.Fitzgerald, T.J., Williams, B., and Uyeki, E.M.Effects of antimitotic and anti-inflammatory agents on sodium urate-induced paw swelling in micePharmacology6(5)265-273(1971) 3.Ribichini, F., Joner, M., Ferrero, V., et al.Effects of oral prednisone after stenting in a rabbit model of established atherosclerosisJ. Am. Coll. Cardiol.50(2)176-185(2007)