Innate Immunity

Polyphenol metabolite.

G protein activator peptide

A neuropeptide with diverse biological activities

BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1).

Ferrichrome (iron-free) is a ferric ionophore for Ustilago sphaerogena , which can serve as a source of iron for the enzyme ferrochelatase.

Sulochrina es un metabolito fúngico producido por A.

BC-1215 es un inhibidor de la proteÍna 3 de la caja F (Fbxo3).

Diapocynin is the dimeric form of the NADPH oxidase inhibitor apocynin that has anti-inflammatory and antioxidant activities.

Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.

Un ácido graso trihidroxilado que contiene un tetraeno conjugado.

Concanavalin A pertenece a los concanamicinas, una familia de antibióticos macrólidos aislados de Streptomyces diastatochromogenes, que son inhibidores altamente activos y selectivos de la vacuolar proton-ATPasa (v-[H[+]]ATPasa).

p38 MAPK Inhibitor IV es un p38α altamente especÍfico competitivo con ATP; inhibidor de MAPK con IC50 de 0,13 y 0,55 μ M para p38α y p38β MAPK, respectivamente.

MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both).

11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.

Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4.

Lipoxin B4 (LXB4) is a positional isomer of LXA4 produced by the metabolism of 15-HETE or 15(S)-HpETE by human leukocytes.

La (Rac)-benpirina, un racemato de la benpirina, es un inhibidor potente y activo por vía oral del TNF-α.

The NF-κB/Rel family of transcription factors induce and coordinate the expression of pro-inflammatory genes including cytokines, chemokines, interferons, MHC proteins, growth factors, and cell adhesion molecules.

SGA360 suprime la seÑalizaciÓn inflamatoria de SAA1 de una manera dependiente de AHR a través de un mecanismo que no requiere la uniÓn de AHR a su elemento de respuesta afÍn (antagonista parcial) .

Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities.

CAY10526 es un inhibidor espec&Iacute;fico de la PGE2 sintasa-1 microsomal (mPGES1). CAY10526 inhibe la producci&Oacute;n de PGE2 a trav&eacute;s de la modulaci&Oacute;n selectiva de la expresi&Oacute;n de mPGES1 pero no afecta a la COX-2. CAY10526 suprime significativamente el crecimiento tumoral y aumenta la apoptosis en xenoinjertos de melanoma. CAY10526 reduce los niveles de prote&Iacute;na BCL-2 y BCL-XL (antiapopt&Oacute;ticos) y aumenta los niveles de BAX y BAK (proapopt&Oacute;ticos), as&Iacute; como los niveles de caspasa 3 escindida. CAY10526 inhibe la viabilidad celular (IC50<5 μM) en tres l&Iacute;neas celulares de melanoma que expresan mPGES1.

A stable analog of PGF 2α 2glyceryl ester

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations.