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Melanocortin (MC) Receptors

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Melanocortin receptors (MCRs) comprise a family of five, class A, G protein-coupled receptors designated MC1R-MC5R with diverse physiological roles. MCRs are found in chordates and are regarded as having evolved from a single ancestral receptor, possibly corresponding most closely to MC4R. Signaling by MCRs has primarily been observed as occurring through the stimulatory α unit Gs which activates adenylyl cyclase to produce cAMP.

The central nervous melanocortin system is involved in energy homeostasis, regulating food intake and energy expenditure. The brain melanocortin system is defined as the primary neurons that express neuropeptide ligands, and secondary neurons expressing the predominant neural melanocortin receptors (MC3R, MC4R). Mutations in the gene encoding melanocortin receptor agonists, or the genes encoding MC3R or MC4R cause obesity. The other members of the melanocortin receptor family are primarily expressed in the periphery, and are involved in regulating pigmentation (MC1R), adrenal gland function (MC2R), immune function (MC1R/MC3R), and sebaceous gland activity (MC5R).

Products Related to Melanocortin (MC) Receptors(57)

  • GC72325 structure
    GC72325hMC1R agonist 1
    CAS: 3028881-87-7

    (EC50=3 nM). hMC1R agonist 1 muestra al menos 300 veces selectividad para hMC1R sobre hMC3R (b>EC50=902 nM), hMC4R (b>EC50=915 nM), y hMC5R (b>EC50=>1000 nM).

  • GC72893 structure
    GC72893MK-0493 hydrochloride
    CAS: 455957-71-8
    Purity: >98.00%

    MK-0493 hydrochloride es un potente agonista activo oral y selectivo del receptor 4 de melanocortina (MC4R), demostrando reducciones significativas en la ingesta de energía.

  • GC73162 structure
    GC73162(2R,2R)-PF-07258669
    CAS: 2755890-68-5

    (2R,2R)-PF-07258669 es un antagonista del receptor MC4R melanocortina 4.

  • GC74361 structure
    GC74361Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)
    Purity: >95.00%

    Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA) es un fragmento de agoutirelacionado con la proteína AGRP que es una proteína que se encuentra en abundancia en el núcleo arcuate del potálamo.

  • GC74400 structure
    GC74400Tetrapeptide-1
    CAS: 1632354-04-1
    Purity: >99.00%

    Tetrapeptide-1 es un péptido bioactivo con efecto antioxidante y se ha utilizado como ingrediente cosmé.

  • GC79292 structure
    GC79292PG-901
    CAS: 322639-20-3
    Purity: >99.00%

    PG-901 is a full, selective MC5R agonist ( EC 50 = 0.072 nM for hMC5R).

  • GC79298 structure
    GC79298PRAME peptide (425-433) acetate
    Purity: >98.00%

    PRAME peptide (425-433) acetate is a proteasome-degraded peptide derived from the cancer-testis antigen PRAME (Preferentially Expressed Antigen in Melanoma ).

  • GC79299 structure
    GC79299Modimelanotide acetate
    Purity: >98.00%

    Modimelanotide (ABT-719) acetate is an α-melanocyte-stimulating hormone analog.

  • GC81662 structure
    GC81662nor-MC3
    CAS: 2870681-06-2
    Purity: >98.00%

    nor-MC3 is an MC3 -type ionizable lipid with C 17 unsaturated chains, formulated in lipid nanoparticles for nucleic acid ( mRNA and siRNA) delivery and supports in vitro and in vivo transfection [1] .