GLPBio

TGF-β Receptor

Read More about this category

TGF-β receptors (Transforming growth factor-β receptors) are single pass serine/threonine kinase receptors. Transforming growth factor beta (TGF-beta) is a member of a large family of pleiotropic cytokines that are involved in many biological processes, including growth control, differentiation, migration, cell survival, adhesion, and specification of developmental fate, in both normal and diseased states. TGF-beta superfamily members signal through a receptor complex comprising a type II and type I receptor, both serine/threonine kinases.

The type I receptors, referred to as activin receptor-like kinases (ALK), lie at the epicenter of the signaling cascade as they transduce TGF-beta signals to intracellular regulators of transcription known as Smad proteins. ALKs possess an extracellular binding domain, a transmembrane domain, a GS domain that serves as the site of activation by type II receptors, and a kinase domain that activates downstream signaling molecules. ALKs mediate the effect of TGF-beta superfamily on a variety of cellular processes such as proliferation, differentiation, apoptosis, adhesion and migration, and therefore play important roles in many biological processes. Some ALKs have been implicated in several disorders, including tumorigenesis and immune diseases, suggesting that these receptors can be used as drug targets.

Products Related to TGF-β Receptor(62)

  • GC72448 structure
    GC72448Dalutrafusp alfa
    CAS: 2419918-89-9
    Purity: >96.00%

    Dalutrafusp alfa (AGEN-1423; GS-1423) es un anticuerpo bifuncional específico contra CD73 y TGF- -, que está implicado en la vía inmunosupres.

  • GC72815 structure
    GC72815Itacnosertib (hydrocholide)
    CAS: 2409543-84-4
    Purity: >99.00%

    Itacnosertib (hydrocholide) es un inhibidor de JAK2, ACVR1 ALK2 y ALK5.

  • GC72917 structure
    GC72917BUR1
    CAS: 23000-46-6
    Purity: >99.00%

    BUR1 es un BMP upregulator (EC50: 98 nM) y activa la señalización BMPRII.

  • GC73292 structure
    GC73292THRX-144644
    CAS: 2442519-59-5
    Purity: >99.00%

    THRX-144644 es un inhibidor de ALK5 restringido a los pulmones con un valor de IC50 de 0,14 nM.

  • GC73338 structure
    GC73338ALK5-IN-34
    CAS: 2785430-90-0
    Purity: >98.00%

    ALK5-IN-34 es un inhibidor selectivo de la quinasa similar al receptor de la activina (ALK).

  • GC73535 structure
    GC73535BMPR2-IN-1 TFA
    Purity: >99.00%

    BMPR2-IN-1 TFA (compuesto 8a) es un inhibidor BMPR2 con un IC50 de 506 nM y un KD de 83,5 nM.

  • GC74516 structure
    GC74516Bintrafusp alfa
    CAS: 1918149-01-5
    Purity: >97.00%

    Bintrafusp alfa (M 7824) es la primera proteína de fusión bifuncional en su clase compuesta del dominio extracelular de TGF- - - RII fusiona a un ligligde IgG1 mAb humano que bloquea la muerte celular programada.

  • GC74617 structure
    GC74617SHR-1701
    CAS: 2891860-17-4
    Purity: >99.00%

    SHR-1701 (Retlirafusp alfa) es una proteína de fusión bifuncional dirigida a PD-L1 y TGF-β para la investigación del cáncer.

  • GC80859 structure
    GC80859RepSox-d 5
    Purity: >98%

    RepSox -d 5 (E-616452-d 5 ) is the deuterium labeled RepSox.

  • GC81350 structure
    GC81350THR-123 TFA
    Purity: >99.50%

    THR-123 TFA is an orally active ALK3 peptide agonist.

  • GC81351 structure
    GC81351Endotrophin (Mus musculus) TFA
    Purity: >96.50%

    Endotrophin (Mus musculus) TFA is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice.

  • GC81352 structure
    GC81352Anti-ALK7 Antibody
    Purity: >97.50%

    Anti-ALK7 Antibody is a monoclonal antibody that targets ALK7.

  • GC81353 structure
    GC81353PF-07868489
    Purity: >99.00%

    PF-07868489 is a recombinant monoclonal antibody targeting GDF2/BMP-9.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.