SR 7826 |
| Catalog No.GC50219 |
SR 7826 es una clase de inhibidor de la quinasa LIM (LIMK) potente, selectivo y activo por vía oral derivado de bis-ariluurea con una IC50 de 43 nM para LIMK1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1219728-20-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective LIMK inhibitor (IC50 values are 43, 5536 and 6565 nM for LIMK1, ROCKI and ROCKII, respectively). Inhibits cofilin phosphorylation in A7r5 cells and suppresses migration and invasion of PC-3 cells in vitro. Orally bioavailable.
Yin et al (2015) Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J.Med.Chem. 58 1846 PMID:25621531
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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