GLPBio

ZEN-3219

Catalog No.: GC84452Purity:>99.50%
COASDSData Sheet
ZEN-3219 is a BET inhibitor with IC50 s of 0.48, 0.16 and 0.47 μM for BRD4 (BD1), BRD4 (BD2) and BRD4 (BD1BD2), respectively.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

ZEN-3219
Cas No.: 1952264-34-4
10mM (in 1mL DMSO)In Stock
$61.00
1
1mgIn Stock
$23.00
1
5mgIn Stock
$56.00
1
10mgIn Stock
$84.00
1
25mgIn Stock
$150.00
1
50mgIn Stock
$225.00
1
100mgIn Stock
$338.00
1
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Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

ZEN-3219 is a BET inhibitor with IC50 s of 0.48, 0.16 and 0.47 μM for BRD4 (BD1), BRD4 (BD2) and BRD4 (BD1BD2), respectively. ZEN-3219 can be used to form PROTAC s to induce degradation of BRD4 [1].

References:
[1]. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018 Sep 27;61(18):8202-8211.

Documentos del producto (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
1952264-34-4
Fórmula molecular
C19H18N2O3
Peso molecular
322.36
Solubilidad
DMSO: 25 mg/mL (77.55 mM; Need ultrasonic)
Almacenamiento
Store at -20°C
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

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