GLPBio

Stafib-2

Catalog No.: GC63204Purity:>95.00%
COASDSData Sheet
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively.

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Stafib-2
Cas No.: 2097938-74-2
10mM (in 1mL DMSO)In Stock
$638.10
1
5 mgIn Stock
$450.00
1
10 mgIn Stock
$765.00
1
25 mgIn Stock
$1,620.00
1
50 mgIn Stock
$2,700.00
1
100 mgIn Stock
$4,140.00
1
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Description

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability[1].

Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM)[1].Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells[1].

[1]. Elumalai N, et, al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819.

Product Documents

Purity:>95.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
2097938-74-2
Molecular Formula
C28H26N2O12P2
Molecular Weight
644.46
Solubility
DMSO : 50 mg/mL (77.58 mM; Need ultrasonic)
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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