Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

    image loader

    Adding item(s) to cart......

Home >> Signaling Pathways >> JAK/STAT Signaling >> STAT

STAT

STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.

Products for  STAT

  1. Cat.No. Product Name Information
  2. GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. (E/Z)-AG490 Chemical Structure
  3. GC12578 (R)-Lisofylline

    (−)-Lisofylline,(R)-LSF

     (R)-Lisofylline is a small molecule compound with anti-inflammatory properties, acting as a lysophosphatidic acid acyltransferase inhibitor (IC₅₀ = 0.6µM). (R)-Lisofylline Chemical Structure
  4. GC69836 (R,R)-VVD-118313

    (R,R)-VVD-118313 is an isomer of VVD-118313. VVD-118313 is a selective JAK1 inhibitor that can block JAK1-dependent phosphorylation and cytokine signaling. VVD-118313 can be used for cancer research.

     (R,R)-VVD-118313 Chemical Structure
  5. GC46503 2-NP

    2-(1,8-Naphthyridin-2-yl)phenol

     2-NP is a cell-penetrating, selective signal transduction and transcription activator 1 (STAT1) transcription enhancer. 2-NP Chemical Structure
  6. GC12138 5,15-DPP

    5,15-Diphenylporphyrin,STAT3 Inhibitor VIII

     5,15-DPP (5,15-DPP) is a selective STAT3-SH2 antagonist (IC50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively). 5,15-DPP Chemical Structure
  7. GC74308 5-FAM-GpYLPQTV-NH2 5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 Chemical Structure
  8. GC74309 5-FAM-GpYLPQTV-NH2 TFA 5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 TFA Chemical Structure
  9. GF17531 8-Epixanthatin 8-Epixanthatin is a light-induced growth inhibitor that regulates the phototropic curvature in sunflower hypocotyls. 8-Epixanthatin Chemical Structure
  10. GC62272 AC-4-130 AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). AC-4-130 Chemical Structure
  11. GC13854 AG-490 (Tyrphostin B42)

    Tyrphostin AG-490

     AG-490 (Tyrphostin B42) is EGFR inhibitor with IC50 of 0.1 µM, AG-490 also has an inhibitory effect on JAK2. AG-490 (Tyrphostin B42) Chemical Structure
  12. GC73203 AK-2292 AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0.10 μM. AK-2292 Chemical Structure
  13. GN10705 Alantolactone

    (+)-Alantolactone, NSC 333843, NSC 93131

     Alantolactone Chemical Structure
  14. GC60585 Angoline Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. Angoline Chemical Structure
  15. GC60586 Angoline hydrochloride Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. Angoline hydrochloride Chemical Structure
  16. GC74306 APT STAT3 APT STAT3 is a specific STAT3-binding peptide. APT STAT3 Chemical Structure
  17. GC10439 APTSTAT3-9R STAT3 inhibitor APTSTAT3-9R Chemical Structure
  18. GC35395 Arnicolide D

    ARD

     Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  19. GC10889 Artesunate

    Artesunic Acid, NSC 712571, WR 256283

     Artesunate is an antimalarial compound and an inhibitor of signal transducer and activator of transcription 3 (STAT-3) and membrane glutathione S-transferase (EXP1). Artesunate Chemical Structure
  20. GC19039 AS1517499 AS1517499 is a potent and brain-permeable STAT6 inhibitor with IC50 of 21 nM. AS1517499 often plays a role in the treatment of renal fibrosis and Keloids. AS1517499 Chemical Structure
  21. GC61574 AS1810722 AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 Chemical Structure
  22. GC38736 AS2863619 AS2863619 is an orally administered small molecule inhibitor of cyclin-dependent kinase (CDK) 8 and 19 with IC50 of 0.6099nM and 4.277nM, respectively. AS2863619 Chemical Structure
  23. GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base Chemical Structure
  24. GC40715 Ascochlorin

    Antibiotic LL-Z1272γ, Ilicicolin D, NSC 287492

     Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. Ascochlorin Chemical Structure
  25. GN10627 Atractylenolide I Atractylenolide I Chemical Structure
  26. GC18126 Balsalazide anti-inflammatory drug Balsalazide Chemical Structure
  27. GC35466 Balsalazide sodium hydrate Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. Balsalazide sodium hydrate Chemical Structure
  28. GC34063 BP-1-102 A STAT3 inhibitor BP-1-102 Chemical Structure
  29. GC42974 Brassinin

    BSN

     Brassinin (BSN) is a phytoalexin isolated from B. Brassinin Chemical Structure
  30. GC35554 Brevilin A

    6-O-Angeloylprenolin, Brevelin A

     A sesquiterpene lactone with anticancer activity Brevilin A Chemical Structure
  31. GC34076 C188-9

    TTI-101

     A STAT3 inhibitor C188-9 Chemical Structure
  32. GC47061 CAY10763 A dual inhibitor of IDO1 and STAT3 activation CAY10763 Chemical Structure
  33. GC49139 CAY10784 A STAT3 inhibitor CAY10784 Chemical Structure
  34. GC35651 Cenisertib

    AS-703569; R-763

     Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  35. GC34238 CMD178 CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. CMD178 Chemical Structure
  36. GC35715 CMD178 TFA CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. CMD178 TFA Chemical Structure
  37. GC14854 Colivelin Colivelin (CLN) is A brain-permeable neuroprotective peptide that has effective long-term effects on Aβ deposition, neuronal apoptosis and synaptic plasticity defects in neurodegenerative diseases. Colivelin Chemical Structure
  38. GC35720 Colivelin TFA Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3?in vitro. Colivelin TFA Chemical Structure
  39. GC50347 CORM 2 CORM 2 is a carbon monoxide-releasing molecule that can liberate a controlled amount of CO in biological systems and has been developed as a carbon monoxide donor. CORM 2 Chemical Structure
  40. GC13279 Corylifol A

    Corylinin

     STAT3 inhibitor Corylifol A Chemical Structure
  41. GN10501 Cryptotanshinone Cryptotanshinone is a natural compound extracted from the roots of Salvia miltiorrhiza Bunge, exhibiting antitumor activity by inhibiting Signal Transducer and Activator of Transcription 3 (STAT3) with an IC50 value of 4.6μM. Cryptotanshinone Chemical Structure
  42. GC13347 Cucurbitacin I

    Elatericin B; JSI-124; NSC-521777

     Cucurbitacin I is a selective Janus Kinase (JAK)/STAT3 signaling pathway inhibitor with an IC50 value of 500nM in A549. Cucurbitacin I Chemical Structure
  43. GN10442 Curculigoside Curculigoside Chemical Structure
  44. GC65020 Danvatirsen

    AZD9150

    Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.

     Danvatirsen Chemical Structure
  45. GC73109 Danvatirsen sodium

    AZD9150 sodium

     Danvatirsen sodium is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen sodium Chemical Structure
  46. GC43406 Delphinidin (chloride)

    Ephdine

     Delphinidin (chloride) is one of the common monomeric forms of anthocyanins, isolated from berries and red wine. Delphinidin (chloride) Chemical Structure
  47. GC34101 Dihydroisotanshinone I Dihydroisotanshinone I is a phenanthrenequinone derivative isolated from the roots of Salvia trijuga, with antioxidant effects. Dihydroisotanshinone I Chemical Structure
  48. GN10115 Diosgenin

    Nitogenin, NSC 33396, 3β-hydroxy-5-Spirostene

     Diosgenin is a naturally occurring steroidal sapogenin that can inhibit the STAT3 signaling pathway and acts as an activator of Pdia3/ERp57, possessing a variety of important pharmacological activities. Diosgenin Chemical Structure
  49. GC33170 ENMD-119 (ENMD 1198)

    IRC-110160

     ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization. ENMD-119 (ENMD 1198) Chemical Structure
  50. GC72862 Erasin Erasin is a potent Erlotinib -resistance antagonizing STAT3 inhibitor with IC50s of 9.7 and 24 μM against STAT3 and STAT1, respectively. Erasin Chemical Structure
  51. GC36016 Eupalinolide K Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) . Eupalinolide K Chemical Structure
  52. GC16875 FLLL32

    JAK2 Inhibitor X

     STAT3 inhibitor FLLL32 Chemical Structure
  53. GC14144 Fludarabine

    2-fluoro-ara-A, NSC 118218

     Fludarabine is a purine analog that inhibits DNA synthesis. Fludarabine Chemical Structure
  54. GC15134 Fludarabine Phosphate (Fludara)

    Fludura

     Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. Fludarabine Phosphate (Fludara) Chemical Structure
  55. GC38044 Fraxinellone Fraxinellone Chemical Structure
  56. GC13285 Galiellalactone inhibits IL-6-mediated JAK/STAT signal transduction Galiellalactone Chemical Structure
  57. GN10696 Garcinone C Garcinone C Chemical Structure
  58. GN10741 Garcinone D Garcinone D Chemical Structure
  59. GC36174 Golotimod

    SCV 07; Gamma-D-glutamyl-L-tryptophan

     Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod Chemical Structure
  60. GC36175 Golotimod (TFA)

    SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA

     Golotimod (TFA) Chemical Structure
  61. GC38386 Golotimod hydrochloride

    SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride

     Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride Chemical Structure
  62. GC50343 HJC 0416 hydrochloride STAT3 inhibitor HJC 0416 hydrochloride Chemical Structure
  63. GC32807 HJC0152 hydrochloride An orally bioavailable inhibitor of STAT3 HJC0152 hydrochloride Chemical Structure
  64. GC16208 HO-3867 STAT3 inhibitor, selective HO-3867 Chemical Structure
  65. GN10742 Homoharringtonine

    NSC 141633, Omacetaxine Mepesuccinate

     Homoharringtonine is a protein synthesis inhibitor and a cytotoxic alkaloid, originally isolated from the evergreen tree Cephalotaxus hainanensis. It is often used in the research of lung cancer and breast cancer. Homoharringtonine Chemical Structure
  66. GC67958 HP590 HP590 Chemical Structure
  67. GC74335 Icotrokinra

    JNJ-77242113; JNJ-2113; PN-235

     Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra Chemical Structure
  68. GC73962 iHSP110-33

    iHSP110-33 is an inhibitor for heat shock protein 110 (HSP110).

     iHSP110-33 Chemical Structure
  69. GB62277 iJak-381

    iJak381; iJak 381; iJak-381; GDC-0214; GDC 0214; GDC0214;

     iJAK-381 is a novel, small-molecule inhibitor selectively targeting the Janus kinase (JAK) family, including JAK1, JAK2, JAK3 and TYK with IC50 values of 8.52, 53.4, 5998 and 240nM respectively at 1mM ATP. iJak-381 Chemical Structure
  70. GC32862 inS3-54A18 inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. inS3-54A18 Chemical Structure
  71. GC34178 Isocryptotanshinone Isocryptotanshinone Chemical Structure
  72. GC69300 IST5-002

    N6-Benzyladenosine-5'-phosphate

    IST5-002 is an effective inhibitor of Stat5a/b, selectively inhibiting the transcriptional activity of Stat5a/b with IC50 values of 1.5 μM (Stat5a) and 3.5 μM (Stat5b). IST5-002 induces apoptosis and death in prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used for research on prostate cancer and CML.

     IST5-002 Chemical Structure
  73. GC15731 L002

    p300/CBP Inhibitor VI, NSC 764414

     p300 inhibitor L002 Chemical Structure
  74. GC73219 LL-K8-22 LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 Chemical Structure
  75. GC69384 LLL12 LLL12 is a specific small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3) that inhibits STAT3 phosphorylation. LLL12 Chemical Structure
  76. GC67706 LY5 LY5 Chemical Structure
  77. GC44213 ML115

    CID 6619100, SID 14735210

     Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 Chemical Structure
  78. GC44227 MM-206 MM-206 is an inhibitor of STAT3 (IC50 = 1.16 μM in an SPR-based competitive assay). MM-206 Chemical Structure
  79. GC32789 Mogrol Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. Mogrol Chemical Structure
  80. GN10436 Morusin

    Mulberrochromene, NSC 649220

     Morusin is a significant prenylated flavone found in Morus alba (Moraceae) root cortex, which exhibits significant anti-tumor activity in the treatment of prostate cancer. Morusin Chemical Structure
  81. GC11474 Napabucasin

    BBI 608

     STAT3 inhibitor Napabucasin Chemical Structure
  82. GC13586 Niclosamide

    NSC 178296

     Niclosamide, an anthelmintic drug, is the small-molecule inhibitor of STAT3 with an IC50 value of 0.25±0.07μM. Niclosamide Chemical Structure
  83. GC44400 Niclosamide (ethanolamine salt)

    BAY-73, BAY-6076, Bayluscide, HL 2448

     Niclosamide is an anthelmintic drug approved by the US Food and Drug Administration (FDA) for treating intestinal infections of tapeworms . Niclosamide (ethanolamine salt) Chemical Structure
  84. GC15901 Niclosamide monohydrate agent for the treatment of most tapeworm infections Niclosamide monohydrate Chemical Structure
  85. GC14170 Nifuroxazide STAT inhibitor Nifuroxazide Chemical Structure
  86. GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide Nifuroxazide-d4 Chemical Structure
  87. GC14653 NSC 74859

    S3I-201;NSC74859;NSC-74859;S3I 201

     NSC 74859 is a selective STAT3 inhibitor with an IC50 of 86μM. NSC 74859 Chemical Structure
  88. GC69594 NSC-370284

    NSC-370284 is a selective inhibitor of both 10-11 translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). It significantly inhibits TET1 expression levels by targeting STAT3/5.

     NSC-370284 Chemical Structure
  89. GC12712 NT157 NT157 is a selective inhibitor of insulin receptor substrate-1/-2 (IRS-1/2). NT157 Chemical Structure
  90. GC61627 Ochromycinone Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone Chemical Structure
  91. GC72263 OK2 OK2, a specific inhibitor of the CCN2/EGFR interaction, efficiently blocks CCN2/EGFR interaction through binding to the CT domain of CCN2. OK2 Chemical Structure
  92. GC69635 OSM-SMI-10B

    OSM-SMI-10B is a derivative of OSM-SMI-10. Co-incubation of OSM-SMI-10B with Oncostatin M (OSM) significantly reduces STAT3 phosphorylation induced by OSM in cancer cells.

     OSM-SMI-10B Chemical Structure
  93. GN10314 Picroside I

    6’-Cinnamoylcatalpol

     Picroside I Chemical Structure
  94. GC10643 Pimozide

    NSC 170984,Orap,R 6238

     Pimozide is a chemically novel, highly potent and orally long-acting neuroleptic dopamine receptors inhibitor, with Kis of 2.4nM, 0.2nM and 1.8nM for dopamine D2, D3 and D4 receptors, respectively. Pimozide Chemical Structure
  95. GC45756 Pimozide-d4

    R6238-d4

     An internal standard for the quantification of pimozide Pimozide-d4 Chemical Structure
  96. GC71016 PM-43I PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I Chemical Structure
  97. GC71017 PM-81I PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I Chemical Structure
  98. GC34742 Protosappanin A

    Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.

     Protosappanin A Chemical Structure
  99. GC39081 Reticuline Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline Chemical Structure
  100. GN10164 Saikosaponin D Saikosaponin D Chemical Structure
  101. GC69854 Salviolone

    Salviolone is a natural diterpenoid derivative that can combat melanoma cells. Salviolone exhibits multifunctional effects on melanoma by blocking cell cycle progression, STAT3 signaling, and the malignant phenotype of A375 melanoma cells.

     Salviolone Chemical Structure

Items 1 to 100 of 136 total

per page
  1. 1
  2. 2

Set Descending Direction