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Home >> Signaling Pathways >> JAK/STAT Signaling >> STAT

STAT

STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.

Products for  STAT

  1. Cat.No. Product Name Information
  2. GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. (E/Z)-AG490 Chemical Structure
  3. GC69836 (R,R)-VVD-118313

    (R,R)-VVD-118313 is an isomer of VVD-118313. VVD-118313 is a selective JAK1 inhibitor that can block JAK1-dependent phosphorylation and cytokine signaling. VVD-118313 can be used for cancer research.

     (R,R)-VVD-118313 Chemical Structure
  4. GC46503 2-(1,8-Naphthyridin-2-yl)phenol

    2-NP

     2-(1,8-Naphthyridin-2-yl)phenol is a selective enhancer of STAT1 transcription. 2-(1,8-Naphthyridin-2-yl)phenol can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells. 2-(1,8-Naphthyridin-2-yl)phenol Chemical Structure
  5. GC12138 5,15-DPP

    5,15-Diphenylporphyrin,STAT3 Inhibitor VIII

     5,15-DPP (5,15-DPP) is a selective STAT3-SH2 antagonist (IC50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively). 5,15-DPP Chemical Structure
  6. GC62272 AC-4-130 AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML). AC-4-130 Chemical Structure
  7. GC13854 AG-490 (Tyrphostin B42)

    Tyrphostin AG-490

     AG-490 (Tyrphostin B42) (Tyrphostin AG-490 (Tyrphostin B42)) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. AG-490 (Tyrphostin B42) Chemical Structure
  8. GN10705 Alantolactone

    (+)-Alantolactone, NSC 333843, NSC 93131

     Alantolactone Chemical Structure
  9. GC60585 Angoline Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. Angoline Chemical Structure
  10. GC60586 Angoline hydrochloride Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation. Angoline hydrochloride Chemical Structure
  11. GC10439 APTSTAT3-9R STAT3 inhibitor APTSTAT3-9R Chemical Structure
  12. GC35395 Arnicolide D

    ARD

     Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner. Arnicolide D Chemical Structure
  13. GC10889 Artesunate

    Artesunic Acid, NSC 712571, WR 256283

     Derivative of the natural product artemisinin Artesunate Chemical Structure
  14. GC19039 AS1517499 A potent STAT6 inhibitor AS1517499 Chemical Structure
  15. GC61574 AS1810722 AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 Chemical Structure
  16. GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19 AS2863619 Chemical Structure
  17. GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases. AS2863619 free base Chemical Structure
  18. GC40715 Ascochlorin

    Antibiotic LL-Z1272γ, Ilicicolin D, NSC 287492

     Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. Ascochlorin Chemical Structure
  19. GN10627 Atractylenolide I Atractylenolide I Chemical Structure
  20. GC18126 Balsalazide anti-inflammatory drug Balsalazide Chemical Structure
  21. GC35466 Balsalazide sodium hydrate Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. Balsalazide sodium hydrate Chemical Structure
  22. GC34063 BP-1-102 A STAT3 inhibitor BP-1-102 Chemical Structure
  23. GC42974 Brassinin

    BSN

     Brassinin (BSN) is a phytoalexin isolated from B. Brassinin Chemical Structure
  24. GC35554 Brevilin A

    6-O-Angeloylprenolin, Brevelin A

     A sesquiterpene lactone with anticancer activity Brevilin A Chemical Structure
  25. GC34076 C188-9

    TTI-101

     A STAT3 inhibitor C188-9 Chemical Structure
  26. GC47061 CAY10763 A dual inhibitor of IDO1 and STAT3 activation CAY10763 Chemical Structure
  27. GC49139 CAY10784 A STAT3 inhibitor CAY10784 Chemical Structure
  28. GC35651 Cenisertib

    AS-703569; R-763

     Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia. Cenisertib Chemical Structure
  29. GC34238 CMD178 CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. CMD178 Chemical Structure
  30. GC35715 CMD178 TFA CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development. CMD178 TFA Chemical Structure
  31. GC14854 Colivelin Colivelin (CLN) is A brain-permeable neuroprotective peptide that has effective long-term effects on Aβ deposition, neuronal apoptosis and synaptic plasticity defects in neurodegenerative diseases. Colivelin Chemical Structure
  32. GC35720 Colivelin TFA Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3?in vitro. Colivelin TFA Chemical Structure
  33. GC13279 Corylifol A

    Corylinin

     STAT3 inhibitor Corylifol A Chemical Structure
  34. GN10501 Cryptotanshinone Cryptotanshinone Chemical Structure
  35. GC13347 Cucurbitacin I

    Elatericin B; JSI-124; NSC-521777

     An inhibitor STAT3/JAK signaling Cucurbitacin I Chemical Structure
  36. GN10442 Curculigoside Curculigoside Chemical Structure
  37. GC65020 Danvatirsen

    AZD9150

     Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth. Danvatirsen Chemical Structure
  38. GC43406 Delphinidin (chloride)

    Ephdine

    Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.

     Delphinidin (chloride) Chemical Structure
  39. GC34101 Dihydroisotanshinone I Dihydroisotanshinone I Chemical Structure
  40. GN10115 Diosgenin

    Nitogenin, NSC 33396, 3β-hydroxy-5-Spirostene

     Diosgenin Chemical Structure
  41. GC33170 ENMD-119 (ENMD 1198)

    IRC-110160

     ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization. ENMD-119 (ENMD 1198) Chemical Structure
  42. GC36016 Eupalinolide K Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) . Eupalinolide K Chemical Structure
  43. GC16875 FLLL32

    JAK2 Inhibitor X

     STAT3 inhibitor FLLL32 Chemical Structure
  44. GC14144 Fludarabine

    2-fluoro-ara-A, NSC 118218

     DNA synthsis inhibitor Fludarabine Chemical Structure
  45. GC15134 Fludarabine Phosphate (Fludara)

    Fludura

     Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis. Fludarabine Phosphate (Fludara) Chemical Structure
  46. GC38044 Fraxinellone Fraxinellone Chemical Structure
  47. GC13285 Galiellalactone inhibits IL-6-mediated JAK/STAT signal transduction Galiellalactone Chemical Structure
  48. GN10696 Garcinone C Garcinone C Chemical Structure
  49. GN10741 Garcinone D Garcinone D Chemical Structure
  50. GC36174 Golotimod

    SCV 07; Gamma-D-glutamyl-L-tryptophan

     Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod Chemical Structure
  51. GC36175 Golotimod (TFA)

    SCV 07 TFA; Gamma-D-glutamyl-L-tryptophan TFA

     Golotimod (TFA) Chemical Structure
  52. GC38386 Golotimod hydrochloride

    SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride

     Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride Chemical Structure
  53. GC50343 HJC 0416 hydrochloride STAT3 inhibitor HJC 0416 hydrochloride Chemical Structure
  54. GC32807 HJC0152 hydrochloride An orally bioavailable inhibitor of STAT3 HJC0152 hydrochloride Chemical Structure
  55. GC16208 HO-3867 STAT3 inhibitor, selective HO-3867 Chemical Structure
  56. GN10742 Homoharringtonine

    NSC 141633, Omacetaxine Mepesuccinate

     Homoharringtonine Chemical Structure
  57. GC67958 HP590 HP590 Chemical Structure
  58. GC32862 inS3-54A18 inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. inS3-54A18 Chemical Structure
  59. GC34178 Isocryptotanshinone Isocryptotanshinone Chemical Structure
  60. GC69300 IST5-002

    N6-Benzyladenosine-5'-phosphate

    IST5-002 is an effective inhibitor of Stat5a/b, selectively inhibiting the transcriptional activity of Stat5a/b with IC50 values of 1.5 μM (Stat5a) and 3.5 μM (Stat5b). IST5-002 induces apoptosis and death in prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used for research on prostate cancer and CML.

     IST5-002 Chemical Structure
  61. GC15731 L002

    p300/CBP Inhibitor VI, NSC 764414

     p300 inhibitor L002 Chemical Structure
  62. GC69384 LLL12

    LLL12 is a small molecule inhibitor of STAT3 that inhibits phosphorylation of STAT3. LLL12 enhances the inhibitory effects of cisplatin and paclitaxel on the generation, migration, and growth of ovarian cancer cells.

     LLL12 Chemical Structure
  63. GC67706 LY5 LY5 Chemical Structure
  64. GC44213 ML115

    CID 6619100, SID 14735210

     Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 Chemical Structure
  65. GC44227 MM-206 MM-206 is an inhibitor of STAT3 (IC50 = 1.16 μM in an SPR-based competitive assay). MM-206 Chemical Structure
  66. GC32789 Mogrol Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. Mogrol Chemical Structure
  67. GN10436 Morusin

    Mulberrochromene, NSC 649220

     Morusin Chemical Structure
  68. GC11474 Napabucasin

    BBI 608

     STAT3 inhibitor Napabucasin Chemical Structure
  69. GC13586 Niclosamide

    NSC 178296

     Inhibitor of the STAT3 signaling pathway Niclosamide Chemical Structure
  70. GC44400 Niclosamide (ethanolamine salt)

    BAY-73, BAY-6076, Bayluscide, HL 2448

     Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research. Niclosamide (ethanolamine salt) Chemical Structure
  71. GC15901 Niclosamide monohydrate agent for the treatment of most tapeworm infections Niclosamide monohydrate Chemical Structure
  72. GC14170 Nifuroxazide STAT inhibitor Nifuroxazide Chemical Structure
  73. GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide Nifuroxazide-d4 Chemical Structure
  74. GC14653 NSC 74859

    S3I-201;NSC74859;NSC-74859;S3I 201

     Stat3 inhibitor NSC 74859 Chemical Structure
  75. GC69594 NSC-370284

    NSC-370284 is a selective inhibitor of both 10-11 translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). It significantly inhibits TET1 expression levels by targeting STAT3/5.

     NSC-370284 Chemical Structure
  76. GC12712 NT157 IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway NT157 Chemical Structure
  77. GC61627 Ochromycinone Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone Chemical Structure
  78. GC69635 OSM-SMI-10B

    OSM-SMI-10B is a derivative of OSM-SMI-10. Co-incubation of OSM-SMI-10B with Oncostatin M (OSM) significantly reduces STAT3 phosphorylation induced by OSM in cancer cells.

     OSM-SMI-10B Chemical Structure
  79. GN10314 Picroside I

    6’-Cinnamoylcatalpol

     Picroside I Chemical Structure
  80. GC10643 Pimozide

    NSC 170984,Orap,R 6238

     dopamine receptors inhibitor Pimozide Chemical Structure
  81. GC45756 Pimozide-d4

    R6238-d4

     An internal standard for the quantification of pimozide Pimozide-d4 Chemical Structure
  82. GC71016 PM-43I PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I Chemical Structure
  83. GC71017 PM-81I PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I Chemical Structure
  84. GC34742 Protosappanin A

    Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.

     Protosappanin A Chemical Structure
  85. GC39081 Reticuline Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline Chemical Structure
  86. GN10164 Saikosaponin D Saikosaponin D Chemical Structure
  87. GC69854 Salviolone

    Salviolone is a natural diterpenoid derivative that can combat melanoma cells. Salviolone exhibits multifunctional effects on melanoma by blocking cell cycle progression, STAT3 signaling, and the malignant phenotype of A375 melanoma cells.

     Salviolone Chemical Structure
  88. GC25899 SC-1

    1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7

     SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation. SC-1 Chemical Structure
  89. GC61524 SC-43 SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. SC-43 Chemical Structure
  90. GN10624 Scutellarin

    Scutellarein 7-O-β-D-glucuronide

     Scutellarin Chemical Structure
  91. GC44880 SD 1029

    JAK2 Inhibitor III, Janus-Associated Kinase 2 Inhibitor III

     A JAK2 inhibitor SD 1029 Chemical Structure
  92. GC14658 SH-4-54 STAT inhibitor, potent SH-4-54 Chemical Structure
  93. GC32928 SH5-07 SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9 μM in in vitro assay. SH5-07 Chemical Structure
  94. GC17761 STA-21

    Ochromycinone

     A STAT3 inhibitor STA-21 Chemical Structure
  95. GC62559 Stafia-1 Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members. Stafia-1 Chemical Structure
  96. GC63203 Stafia-1-dipivaloyloxymethyl ester Stafia-1-dipivaloyloxymethyl ester (compound 27, 0-200 μM) decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b. Stafia-1-dipivaloyloxymethyl ester Chemical Structure
  97. GC62254 Stafib-1 Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM. Stafib-1 Chemical Structure
  98. GC63204 Stafib-2 Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 Chemical Structure
  99. GC52293 STAT3 Inhibitor 4m

    Signal Transducer and Activator of Transcription 3 Inhibitor 4m

     A STAT3 inhibitor STAT3 Inhibitor 4m Chemical Structure
  100. GC37688 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis. STAT3-IN-1 Chemical Structure
  101. GC69952 STAT3-IN-11

    STAT3-IN-11 (7a) is a selective inhibitor of STAT3 that can inhibit the phosphorylation of the pTyr705 site on STAT3. It can also inhibit downstream genes (Survivin and Mcl-1) without affecting upstream tyrosine kinases (Src and JAK2) and p-STAT1 expression. STAT3-IN-11 can induce apoptosis in cancer cells, making it a promising candidate for the discovery of STAT3 inhibitors and anti-tumor agents.

     STAT3-IN-11 Chemical Structure

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