STAT
STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.
Products for STAT
- Cat.No. Product Name Information
- GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
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GC69836
(R,R)-VVD-118313
(R,R)-VVD-118313 is an isomer of VVD-118313. VVD-118313 is a selective JAK1 inhibitor that can block JAK1-dependent phosphorylation and cytokine signaling. VVD-118313 can be used for cancer research.
- GC46503 2-(1,8-Naphthyridin-2-yl)phenol 2-(1,8-Naphthyridin-2-yl)phenol is a selective enhancer of STAT1 transcription. 2-(1,8-Naphthyridin-2-yl)phenol can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells.
- GC12138 5,15-DPP 5,15-DPP (5,15-DPP) is a selective STAT3-SH2 antagonist (IC50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively).
- GC62272 AC-4-130 AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML).
- GC13854 AG-490 (Tyrphostin B42) AG-490 (Tyrphostin B42) (Tyrphostin AG-490 (Tyrphostin B42)) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
- GN10705 Alantolactone
- GC60585 Angoline Angoline is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
- GC60586 Angoline hydrochloride Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.
- GC10439 APTSTAT3-9R STAT3 inhibitor
- GC35395 Arnicolide D Arnicolide D is a sesquiterpene lactone isolated from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling pathways. Arnicolide D inhibits Nasopharyngeal carcinoma (NPC) cell viability in a concentration- and time-dependent manner.
- GC10889 Artesunate Derivative of the natural product artemisinin
- GC19039 AS1517499 A potent STAT6 inhibitor
- GC61574 AS1810722 AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM.
- GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19
- GC38737 AS2863619 free base AS2863619 free base enables conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells for the treatment of various immunological diseases.
- GC40715 Ascochlorin Ascochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells.
- GN10627 Atractylenolide I
- GC18126 Balsalazide anti-inflammatory drug
- GC35466 Balsalazide sodium hydrate Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
- GC34063 BP-1-102 A STAT3 inhibitor
- GC42974 Brassinin Brassinin (BSN) is a phytoalexin isolated from B.
- GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
- GC34076 C188-9 A STAT3 inhibitor
- GC47061 CAY10763 A dual inhibitor of IDO1 and STAT3 activation
- GC49139 CAY10784 A STAT3 inhibitor
- GC35651 Cenisertib Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia.
- GC34238 CMD178 CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development.
- GC35715 CMD178 TFA CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development.
- GC14854 Colivelin Colivelin (CLN) is A brain-permeable neuroprotective peptide.
- GC35720 Colivelin TFA Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3?in vitro.
- GC13279 Corylifol A STAT3 inhibitor
- GN10501 Cryptotanshinone
- GC13347 Cucurbitacin I An inhibitor STAT3/JAK signaling
- GN10442 Curculigoside
- GC65020 Danvatirsen Danvatirsen is an antisense oligonucleotide targeting STAT3 with potential antitumor activity. Danvatirsen binds to STAT3 mRNA, thereby inhibiting translation of the transcript. Suppression of STAT3 expression induces tumor cell apoptosis and decreases tumor cell growth.
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GC43406
Delphinidin (chloride)
Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which serves as the precursor of certain anthocyanins that provide the blue-red colors of flowers, fruits, and red wine.
- GC34101 Dihydroisotanshinone I
- GN10115 Diosgenin
- GC33170 ENMD-119 (ENMD 1198) ENMD-119 (ENMD 1198) (IRC-110160), an orally active microtubule destabilizing agent, is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity. ENMD-119 (ENMD 1198) is suitable for inhibiting HIF-1alpha and STAT3 in human HCC cells and leads to reduced tumor growth and vascularization.
- GC36016 Eupalinolide K Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .
- GC16875 FLLL32 STAT3 inhibitor
- GC14144 Fludarabine DNA synthsis inhibitor
- GC15134 Fludarabine Phosphate (Fludara) Fludarabine (phosphate) is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
- GC38044 Fraxinellone
- GC13285 Galiellalactone inhibits IL-6-mediated JAK/STAT signal transduction
- GN10696 Garcinone C
- GN10741 Garcinone D
- GC36174 Golotimod Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
- GC36175 Golotimod (TFA)
- GC38386 Golotimod hydrochloride Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
- GC50343 HJC 0416 hydrochloride STAT3 inhibitor
- GC32807 HJC0152 hydrochloride An orally bioavailable inhibitor of STAT3
- GC16208 HO-3867 STAT3 inhibitor, selective
- GN10742 Homoharringtonine
- GC67958 HP590
- GC32862 inS3-54A18 inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
- GC34178 Isocryptotanshinone
- GC15731 L002 p300 inhibitor
- GC67706 LY5
- GC44213 ML115 Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer.
- GC44227 MM-206 MM-206 is an inhibitor of STAT3 (IC50 = 1.16 μM in an SPR-based competitive assay).
- GC32789 Mogrol Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
- GN10436 Morusin
- GC11474 Napabucasin STAT3 inhibitor
- GC13586 Niclosamide Inhibitor of the STAT3 signaling pathway
- GC44400 Niclosamide (ethanolamine salt) Niclosamide (BAY2353) olamine is an orally active antihelminthic agent used in parasitic infection research.
- GC15901 Niclosamide monohydrate agent for the treatment of most tapeworm infections
- GC14170 Nifuroxazide STAT inhibitor
- GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide
- GC14653 NSC 74859 Stat3 inhibitor
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GC69594
NSC-370284
NSC-370284 is a selective inhibitor of both 10-11 translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). It significantly inhibits TET1 expression levels by targeting STAT3/5.
- GC12712 NT157 IRS-1/2 inhibitor, inhibits IGF-1R and STAT3 signaling pathway
- GC61627 Ochromycinone Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor.
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GC69635
OSM-SMI-10B
OSM-SMI-10B is a derivative of OSM-SMI-10. Co-incubation of OSM-SMI-10B with Oncostatin M (OSM) significantly reduces STAT3 phosphorylation induced by OSM in cancer cells.
- GN10314 Picroside I
- GC10643 Pimozide dopamine receptors inhibitor
- GC45756 Pimozide-d4 An internal standard for the quantification of pimozide
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GC34742
Protosappanin A
Protosappanin A (PTA), an immunosuppressive ingredient and major biphenyl compound isolated from Caesalpinia sappan L, suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3.
- GC39081 Reticuline Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways.
- GN10164 Saikosaponin D
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GC69854
Salviolone
Salviolone is a natural diterpenoid derivative that can combat melanoma cells. Salviolone exhibits multifunctional effects on melanoma by blocking cell cycle progression, STAT3 signaling, and the malignant phenotype of A375 melanoma cells.
- GC25899 SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
- GC61524 SC-43 SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects.
- GN10624 Scutellarin
- GC44880 SD 1029 A JAK2 inhibitor
- GC14658 SH-4-54 STAT inhibitor, potent
- GC32928 SH5-07 SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9 μM in in vitro assay.
- GC17761 STA-21 A STAT3 inhibitor
- GC62559 Stafia-1 Stafia-1 is a potent STAT5a inhibitor (K i=10.9 μM, IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
- GC63203 Stafia-1-dipivaloyloxymethyl ester Stafia-1-dipivaloyloxymethyl ester (compound 27, 0-200 μM) decreases pSTAT5a expression significantly, and has no obvious inhibition on pSTAT5b.
- GC62254 Stafib-1 Stafib-1 is the first selective inhibitor of the STAT5b SH2 domain, with a Ki of 44 nM and an IC50 of 154 nM.
- GC63204 Stafib-2 Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively.
- GC52293 STAT3 Inhibitor 4m A STAT3 inhibitor
- GC37688 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis.
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GC69952
STAT3-IN-11
STAT3-IN-11 (7a) is a selective inhibitor of STAT3 that can inhibit the phosphorylation of the pTyr705 site on STAT3. It can also inhibit downstream genes (Survivin and Mcl-1) without affecting upstream tyrosine kinases (Src and JAK2) and p-STAT1 expression. STAT3-IN-11 can induce apoptosis in cancer cells, making it a promising candidate for the discovery of STAT3 inhibitors and anti-tumor agents.
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GC69953
STAT3-IN-12
STAT3-IN-12 is an effective STAT3 signaling inhibitor that can suppress the activation of the IL-6-induced JAK/STAT3 signaling pathway. It can inhibit cancer cell growth and migration, induce apoptosis (cell death), and block cell cycle progression. STAT3-IN-12 can be used in cancer-related research such as hepatocellular carcinoma (HCC) and esophageal cancer.
- GC37689 STAT3-IN-3 STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.
- GC13647 STAT5 Inhibitor STAT5 Inhibitor is a STAT5 inhibitor with an IC50 of 47 μM for STAT5β isoform.
- GC65344 STAT5-IN-2 STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.