GLPBio

Tautomycetin

Catalog No.: GC11381Purity:>98.00%
COASDSData Sheet
protein phosphatase (PP)1 inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

Tautomycetin
Cas No.: 119757-73-2
50µgQuote
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Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Protocol

Cell experiment [1]:

Cell lines

Human primary T cells

Preparation method

The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

1 μg/ml for 5 h

Applications

Tautomycetin possesses immunosuppressive activity to inhibit the proliferation of T cells by inhibition of IL-2 secretion.
Animal experiment [1]:

Animal models

Rats after heterotopic cardiac transplantation

Dosage form

0.05 mg/kg. Tautomycetin solubilized in PBS or in microemulsion form for 30 days after heterocardiac transplantation.

Application

Immunosuppressive activity of tautomycetin is effective in an in vivo organ transplantation model (rats after heterotopic cardiac transplantation).

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Jae-Hyuck Shim, et al. Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16): 10617–10622.

Product Documents

Purity:>98.00%Appearance:A liquid
COASDSData Sheet

Chemical Properties

CAS No.
119757-73-2
Chemical Name
(S)-(2S,3S,4R,7S,8R,11R,13R,Z)-17-ethyl-4,8-dihydroxy-3,7,11,13-tetramethyl-6,15-dioxononadeca-16,18-dien-2-yl 3-hydroxy-3-(4-methyl-2,5-dioxo-2,5-dihydrofuran-3-yl)propanoate
SMILES
O[C@@H]([C@H](C)C(C[C@H]([C@H](C)[C@H](C)OC(C[C@@H](C1=C(C)C(OC1=O)=O)O)=O)O)=O)CC[C@@H](C)C[C@@H](C)CC(/C=C(C=C)/CC)=O
Molecular Formula
C33H50O10
Molecular Weight
606.75
Solubility
Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)
Storage
Desiccate at -20°C,protect from light
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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