Protein Ser/Thr Phosphatases
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Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.
Products Related to Protein Ser/Thr Phosphatases(23)
- GC11806β-Glycerophosphate (sodium salt hydrate)CAS: 13408-09-8Purity: >98.00%
β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor.
- GC14395Fostriecin sodium saltCAS: 87860-39-7Purity: >95.00%
A potent inhibitor of protein phosphatases 2A and 4
- GC15120PTP Inhibitor ICAS: 2491-38-5Purity: >98.00%
PTP Inhibitor I a PTP1B inhibitor, with a Ki of 42 μM.
- GC15804PTP Inhibitor IICAS: 2632-13-5Purity: >98.00%
PTP Inhibitor II is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect.
- GC15974bpV(HOpic) (potassium salt, technical grade)CAS: 722494-26-0Purity: >95.00%
bpV(HOpic) (potassium salt, technical grade) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM.
- GC16900PRL-3 InhibitorCAS: 893449-38-2Purity: >98.50%
The PRL-3 Inhibitor is an inhibitor of phosphatase of regenerating liver-3 (PRL-3) with an IC 50 of 0.9μM.
- GC17011C2 CeramideCAS: 3102-57-6Purity: >98.00%
C2 Ceramide is a short-chain cell-permeable ceramide analogue that inhibits the protein Bcl2 phosphorylation with an IC 50 value of 14μmol/L.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC17676 | Nafamostat | 81525-10-2 | >98% | |
Nafamostat is a synthetic serine protease inhibitor. | ||||
| GC11381 | Tautomycetin | 119757-73-2 | >98.00% | |
protein phosphatase (PP)1 inhibitor | ||||
| GC11561 | NSC 95397 | 93718-83-3 | >98.00% | |
Cdc25 dual specificity phosphatases inhibitor | ||||
| GC11806 | β-Glycerophosphate (sodium salt hydrate) | 13408-09-8 | >98.00% | |
β-Glycerophosphate (sodium salt hydrate) is a phosphatase inhibitor. | ||||
| GC12082 | Cantharidic Acid (sodium salt) | 1465-77-6 | >98% | |
PP1 and PP2A inhibitor | ||||
| GC12189 | LB-100 | 1026680-07-8 | >98% | |
protein phosphatase 2A(PP2A)inhibitor | ||||
| GC12498 | Sephin1 | 13098-73-2 | >99.50% | |
Sephin1 ((E/Z)-Sephin1) is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). | ||||
| GC12891 | CCT007093 | 176957-55-4 | >98.00% | |
PPM1D inhibitor | ||||
| GC13442 | Sanguinarine chloride | 5578-73-4 | >99.00% | |
Inhibitor of PP2C and MKP-1 | ||||
| GC14024 | DL-AP3 | 5652-28-8 | >95.00% | |
A metabotropic glutamate receptor antagonist | ||||
| GC14395 | Fostriecin sodium salt | 87860-39-7 | >95.00% | |
A potent inhibitor of protein phosphatases 2A and 4 | ||||
| GC14875 | NSC 663284 | 383907-43-5 | >99.50% | |
Cdc25 dual specificity phosphatases inhibitor | ||||
| GC15120 | PTP Inhibitor I | 2491-38-5 | >98.00% | |
PTP Inhibitor I a PTP1B inhibitor, with a Ki of 42 μM. | ||||
| GC15718 | CID 2011756 | 638156-11-3 | >98% | |
An inhibitor of protein kinase D | ||||
| GC15804 | PTP Inhibitor II | 2632-13-5 | >98.00% | |
PTP Inhibitor II is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect. | ||||
| GC15969 | PTP Inhibitor IV | 329317-98-8 | >98% | |
PTP inhibitor | ||||
| GC15974 | bpV(HOpic) (potassium salt, technical grade) | 722494-26-0 | >95.00% | |
bpV(HOpic) (potassium salt, technical grade) is a potent and selective inhibitor of PTEN with an IC50 of 14 nM. | ||||
| GC16117 | INCA-6 | 3519-82-2 | >99.00% | |
A cell-permeant inhibitor of NFAT signaling | ||||
| GC16900 | PRL-3 Inhibitor | 893449-38-2 | >98.50% | |
The PRL-3 Inhibitor is an inhibitor of phosphatase of regenerating liver-3 (PRL-3) with an IC 50 of 0.9μM. | ||||
| GC16958 | Okadaic acid | 78111-17-8 | >95.00% | |
A potent inhibitor of protein phosphatases | ||||
| GC17011 | C2 Ceramide | 3102-57-6 | >98.00% | |
C2 Ceramide is a short-chain cell-permeable ceramide analogue that inhibits the protein Bcl2 phosphorylation with an IC 50 value of 14μmol/L. | ||||
| GC17344 | Alexidine dihydrochloride | 1715-30-6 | >99.00% | |
An alkyl bis(biguanide) antiseptic | ||||
| GC16290 | Nafamostat hydrochloride | 80251-32-7 | >98% | |
Synthetic serine protease inhibitor | ||||