TCB-32 (Compound I-1) hydrochloride is a FGFR1 agonist with an EC 50 of 0.88 μM. TCB-32 hydrochloride significantly increases cell proliferation through activating FGFR1 signaling pathway as bFGF and its downstream ERK1/2 with excellent thermal stability. TCB-32 hydrochloride can replace bFGF in serum-free cell culture media. TCB-32 hydrochloride can be used for tissue repair and wound healing related diseases like psoriasis and eczema research [1] [2].
References:
[1]. FEOFANOV M, et al. Compounds for activation of fgfr1 signaling. WO2025045826A1. 2025-03-06.
[2]. Feofanov M, et al. Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications. Biochem Biophys Rep. 2025 Jul 21;43:102167.
References:
[1]. FEOFANOV M, et al. Compounds for activation of fgfr1 signaling. WO2025045826A1. 2025-03-06.
[2]. Feofanov M, et al. Discovery and optimization of a guanylhydrazone-based small molecule to replace bFGF for cell culture applications. Biochem Biophys Rep. 2025 Jul 21;43:102167.