MAPK Signaling

EHop-016 is a potent inhibitor of Rac GTPase Rac1, with an IC 50 value of 1.1μM.

NSC 23766 trihydrochloride is a selective Rac1 GTPase inhibitor that suppresses Rac1 activation by specifically blocking the guanine nucleotide exchange factors Trio and Tiam1, with an IC₅₀ of approximately 50μM for Rac1.

Allosteric MEK1/2 inhibitor, non-ATP competitive

JNK/c-Jun interaction inhibitor

cAMPS-Rp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.

B-Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.

GW5074 is a potent and selective c-Raf inhibitor (IC 50 =9nM).

Potent B-Raf inhibitor

cAMPS-Sp, triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist.

PD98059 is a potent and selective MEK inhibitor with an IC 50 of 2 μM.

Dibutyryl-cAMP, sodium salt, also known as Bucladesine, is a cell-permeable cyclic nucleotide analogue which mimics the action of endogenous cAMP and acts as a phosphodiesterase inhibitor.

MEK162 (ARRY-162, ARRY-438162) (MEK162) is an oral and selective MEK1/2 inhibitor. MEK162 (ARRY-162, ARRY-438162) (MEK162) inhibits MEK with an IC50 of 12 nM.

VX-745 (VX-745) is a potent, blood-brain barrier penetrant, highly selective inhibitor of p38α inhibitor with an IC50 for p38α of 10 nM and for p38β of 220 nM.

GABAA receptors antagonist

C-Raf inhibitor, potent and selective

P90 RSK inhibitor,ATP-competitive and cell-permeable

MEK 1/2 inhibitor

B-B-Raf inhibitor 1 dihydrochloride is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.

Raf kinases,potent and ATP-competitive

Dabrafenib (GSK2118436) is a potent, selective, and efficacious inhibitor of B-Raf V600E , with therapeutic efficacy against tumors harboring activating B‑Raf mutations.

SL-327 is a selective inhibitor of MEK1 and MEK2, with IC 50 values of 0.18μM and 0.22μM, respectively.

NKCC cotransporter inhibitor

cGMP Dependent Kinase Inhibitor Peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM.

RAF inhibitor