GLPBio

Tesirine intermediate-1

Catalog No.: GC74145Purity:>99.00%
COASDSData Sheet
Tesirine intermediate-1 is the intermediate of Tesirine.

Products are for research use only. Not for human use. We do not sell to patients.

Tesirine intermediate-1
Cas No.: 1430738-05-8
100mgIn Stock
$187.00
1
250mgIn Stock
$312.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

Tesirine intermediate-1 is the intermediate of Tesirine . Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 , which has strong anticancer cell activity.

References:
[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18. [2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1430738-05-8
Molecular Formula
C28H48N2O7Si2
Molecular Weight
580.86
Solubility
DMSO : ≥ 100 mg/mL (172.16 mM)
Storage
-20°C, protect from light, stored under nitrogen
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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