GLPBio

UCB-6876

Catalog No.: GC71380Purity:>99.00%
COASDSData Sheet
UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD = 22 μM).

Products are for research use only. Not for human use. We do not sell to patients.

UCB-6876
Cas No.: 637324-45-9
5 mgIn Stock
$54.00
1
10 mgIn Stock
$86.00
1
25 mgIn Stock
$171.00
1
50 mgIn Stock
$275.00
1
100 mgIn Stock
$432.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

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    641, 529–536 (2025)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

UCB-6876 is a TNFα inhibitor and binds to asymmetrical crystal form of the TNF trimer (KD = 22 μM).

References:
[1]. Eguida M, et al. Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision. J Cheminform. 2021 Nov 23;13(1):90.
[2]. O'Connell J, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019 Dec 19;10(1):5795.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
637324-45-9
Molecular Formula
C17H18N2O
Molecular Weight
266.34
Solubility
DMSO : 100 mg/mL (375.46 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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