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TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

  1. Cat.No. Product Name Information
  2. GC10350 TIC10 isomer

    Potent Akt/ERK inhibitor

  3. GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody) A human monoclonal IgG1 antibody targeting TNF-α
  4. GC35377 Apratastat
  5. GC10420 Apremilast (CC-10004)

    PDE4 inhibitor

  6. GN10415 Astilbin Immunosuppresive. Antiproliferative
  7. GC35440 AX-024
  8. GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A.
  9. GC35523 Bioymifi
  10. GC33826 C 87
  11. GC34513 C25-140
  12. GC33337 CDC801
  13. GC15083 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  14. GC14500 CPI-1189 necrosis factor (TNF) alpha inhibitor
  15. GC33330 Cynaropicrin
  16. GN10030 Fisetin Extracted from Rhus succedanea L;Store the product in sealed, cool and dry condition
  17. GN10727 Forsythoside B Extracted from Forsythia suspense (Thunb.) Vahl dried fruit;Store the product in sealed, cool and dry condition
  18. GN10151 Geraniin Extracted from sandwort;Store the product in sealed, cool and dry condition
  19. GN10254 Ginsenoside Rc Anticancer, antidiabetic and neuroprotective agent
  20. GN10538 Ginsenoside Rh1 Extracted from Panax ginseng C.A.Mey.;Suitability:Water,methanol,ethanol;Store the product in sealed,cool and dry condition
  21. GC15573 GSK481 RIP1(Receptor Interacting Protein Kinase 1) inhibitor

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