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Home >> Signaling Pathways >> Apoptosis >> TNF-α

TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for  TNF-α

  1. Cat.No. Product Name Information
  2. GC10350 TIC10 isomer

    ONC201 isomer

    Potent Akt/ERK inhibitor

     TIC10 isomer Chemical Structure
  3. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

    α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2

     α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) Chemical Structure
  4. GC69795 (Rac)-BIO8898

    (Rac)-BIO8898 is a CD40-CD154 co-stimulatory interaction inhibitor. (Rac)-BIO8898 inhibits the binding of CD154 to CD40-Ig, with an IC50 of 25 μM.

     (Rac)-BIO8898 Chemical Structure
  5. GC63972 5,7-Dimethoxyflavanone 5,7-Dimethoxyflavanone shows potent antimutagenic activity against MeIQ mutagenesis in Ames test using the S. 5,7-Dimethoxyflavanone Chemical Structure
  6. GC45772 6(5H)-Phenanthridinone

    NSC 11021, NSC 40943, NSC 61083

     An inhibitor of PARP1 and 2 6(5H)-Phenanthridinone Chemical Structure
  7. GC35184 7,3',4'-Tri-O-methylluteolin 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin Chemical Structure
  8. GC45960 9c(i472)

    15-LOX-1 Inhibitor i472

     9c(i472) is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 9c(i472) Chemical Structure
  9. GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody) Adalimumab (Anti-Human TNF-alpha, Human Antibody) is one of the leading therapies for the treatment of rheumatoid arthritis. Adalimumab (Anti-Human TNF-alpha, Human Antibody) Chemical Structure
  10. GC72386 Afelimomab Afelimomab (MAK 195F) is an anti-tumor necrosis factor F(ab')2 monoclonal antibody fragment. Afelimomab Chemical Structure
  11. GC72337 Anti-Mouse 4-1BB/CD137 Antibody (3H3) Anti-Mouse 4-1BB/CD137 Antibody (3H3) is an anti-mouse 4-1BB IgG2a antibody inhibitor derived from the host Rat. Anti-Mouse 4-1BB/CD137 Antibody (3H3) Chemical Structure
  12. GC46862 Apigenin-d5

    3,6,8,3’,5’-d5-Apigenin, Chamomile-d5, Flavone-d5, Versulin-d5

     An internal standard for the quantification of apigenin Apigenin-d5 Chemical Structure
  13. GC35377 Apratastat

    TMI-005

     An inhibitor of ADAM17 and MMPs Apratastat Chemical Structure
  14. GC10420 Apremilast (CC-10004)

    APR, CC-10004

     An orally available PDE4 inhibitor Apremilast (CC-10004) Chemical Structure
  15. GN10415 Astilbin

    Taxifolin 3-O-rhamnoside

     Astilbin Chemical Structure
  16. GC74507 Asunercept

    APG101; CAN008

     Asunercept (APG101; CAN008) is a soluble CD95-Fc fusion protein targeting CD95L. Asunercept Chemical Structure
  17. GC42880 Avenanthramide-C methyl ester Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Avenanthramide-C methyl ester Chemical Structure
  18. GC35440 AX-024 AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 Chemical Structure
  19. GC19046 AX-024 hydrochloride AX-024 hydrochloride is an cytokine release inhibitor which can strongly inhibit the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10 and IL-17A. AX-024 hydrochloride Chemical Structure
  20. GC68369 Belantamab

    GSK2857914

     Belantamab Chemical Structure
  21. GC65031 Belimumab Belimumab (LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF). Belimumab Chemical Structure
  22. GC62451 Benpyrine Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine Chemical Structure
  23. GC74515 Benufutamab

    GEN1029

     Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab Chemical Structure
  24. GC42925 Berteroin

    5-Methylthiopentyl isothiocyanate

     Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. Berteroin Chemical Structure
  25. GC67680 BIO8898 BIO8898 Chemical Structure
  26. GC35523 Bioymifi

    DR5 Activator

     A DR5 agonist Bioymifi Chemical Structure
  27. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM). BMS 345541 (trifluoroacetate salt) Chemical Structure
  28. GC71541 BMS-561392 formate BMS-561392 formate is the formate form of BMS-561392 . BMS-561392 formate Chemical Structure
  29. GC74424 Boserolimab

    MK-5890

     Boserolimab (MK-5890) is a humanized agonist monoclonal antibody that binds to CD27 to provide a costimulatory signal that enhances T-cell–mediated responses. Boserolimab Chemical Structure
  30. GC68288 Brentuximab Brentuximab Chemical Structure
  31. GC33826 C 87 C 87 is a novel small-molecule TNFα inhibitor; potently inhibits TNFα-induced cytotoxicity with an IC50 of 8.73 μM. C 87 Chemical Structure
  32. GC34513 C25-140 C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 Chemical Structure
  33. GC70658 C5 Lenalidomide C5 Lenalidomide (Lenalidomide 5'-amine) is a thalidomide analog and is a potent inhibitor of TNF-alpha production (IC50=100 μM in LPS stimulated human PBMC). C5 Lenalidomide Chemical Structure
  34. GC43110 C8 Galactosylceramide (d18:1/8:0)

    Galactosylceramide (d18:1/8:0), N-octanoyl-βD-Galactosylceramide, GalCer(d18:1/8:0)

     C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. C8 Galactosylceramide (d18:1/8:0) Chemical Structure
  35. GC43176 CAY10575

    IKK2 Inhibitor 3, Polo-like Kinase Inhibitor 1

     CAY10575 (Compound 8) is an IKK2 inhibitor with an IC50 of 0.075 μM. CAY10575 Chemical Structure
  36. GC43189 CAY10681 Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 Chemical Structure
  37. GC43190 CAY10682 (±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 Chemical Structure
  38. GC40650 CAY10706 CAY10706 is a ligustrazine-curcumin hybrid that promotes intracellular reactive oxygen species accumulation preferentially in lung cancer cells. CAY10706 Chemical Structure
  39. GC33337 CDC801 CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively. CDC801 Chemical Structure
  40. GC15083 Celastrol Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC50 of 2.5 μM. Celastrol Chemical Structure
  41. GC18392 Cellocidin

    Acetylenedicarboxylic Acid, NSC 38643, NSC 65381

     Cellocidin is an antibiotic originally isolated from S. Cellocidin Chemical Structure
  42. GC65487 Certolizumab pegol Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research. Certolizumab pegol Chemical Structure
  43. GC74542 Cinrebafusp alfa

    PRS 343

     Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa Chemical Structure
  44. GC68882 Cleomiscosin A

    Cleomiscosin A is a coumarin lignan produced by Macaranga adenantha. It has activity in inducing TNF-alpha secretion from mouse peritoneal macrophages.

     Cleomiscosin A Chemical Structure
  45. GC74472 Conatumumab

    AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody

     Conatumumab (AMG 655) is a human monoclonal agonist antibody against human death receptor 5 (DR5, TRAILR2) (Kd: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab Chemical Structure
  46. GC14500 CPI-1189 necrosis factor (TNF) alpha inhibitor CPI-1189 Chemical Structure
  47. GC33330 Cynaropicrin A sesquiterpene lactone Cynaropicrin Chemical Structure
  48. GC43368 D,L-1′-Acetoxychavicol Acetate

    ACA, 1'-Acetoxychavicol Acetate, Galangal Acetate

     D,L-1′-Acetoxychavicol acetate is a natural compound first isolated from the rhizomes of ginger-like plants. D,L-1′-Acetoxychavicol Acetate Chemical Structure
  49. GC60796 D-Trimannuronic acid D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid Chemical Structure
  50. GC68305 Dacetuzumab Dacetuzumab Chemical Structure
  51. GC33934 DCVC

    S-[(1E)-1,2-dichloroethenyl]--L-cysteine

     DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) is a bioactive metabolite of trichloroethylene (TCE). DCVC Chemical Structure
  52. GC72791 Delmitide acetate

    RDP-58 acetate

     Delmitide (RDP58) acetate is an orally active d-isomer decapeptide with potent anti-inflammatory activity. Delmitide acetate Chemical Structure
  53. GC71298 DRI-C21041 (DIEA) DRI-C21041 DIEA is a CD40/CD40L interaction inhibitor, with an IC50 of 0.31 μM. DRI-C21041 (DIEA) Chemical Structure
  54. GC74422 Duvakitug Duvakitug is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug Chemical Structure
  55. GC64864 EJMC-1 EJMC-1 is a moderately potent TNF-α inhibitor with an IC50 value of 42 μM. EJMC-1 Chemical Structure
  56. GC74608 Elranatamab

    PF-06863135

     Elranatamab (PF-06863135) is an anti-CD3E/TNFRSF17 human IgG2κ monoclonal antibody. Elranatamab Chemical Structure
  57. GC69062 Enavatuzumab

    Enavatuzumab (PDL192; ABT-361) is a humanized IgG1 monoclonal antibody that targets the TNF-like weak inducer of apoptosis receptor (TWEAK). TWEAK (Fn14; TNFRSF12A) is the natural ligand for the TweakR receptor and can stimulate various cellular responses. Enavatuzumab induces tumor growth inhibition through direct TweakR signaling and antibody-dependent cell-mediated cytotoxicity (ADCC). Enavatuzumab actively recruits and activates bone marrow effector cells to kill tumor cells. In vitro and in vivo, enavatuzumab inhibits the growth of various human TweakR-positive cancer cell lines and xenografts.

     Enavatuzumab Chemical Structure
  58. GC34579 Etanercept Etanercept is a competitive tumor necrosis factor (TNF) inhibitor that prevents TNF-α and TNF-β from binding to cell surface receptors. Etanercept Chemical Structure
  59. GC30910 Eucalyptol (1,8-Cineole)

    NSC 6171

     A bicyclic monoterpene with diverse biological activities Eucalyptol (1,8-Cineole) Chemical Structure
  60. GC74441 Evunzekibart

    ATOR-1017

     Evunzekibart (ATOR-1017) is an Fc-γ receptor conditional 4-1BB agonist and IgG4-type antibody. Evunzekibart Chemical Structure
  61. GC74430 Exlinkibart

    LVGN-6051

     Exlinkibart (LVGN-6051) targets TNFRSF9 and is an IgG1κ antibody humanized through complementarity-determining region (CDR) grafting technology. Exlinkibart Chemical Structure
  62. GN10030 Fisetin

    CI-75620, NSC 407010, NSC 656275

     Fisetin is a natural flavonol found in many fruits and vegetables with multiple biological activities. Fisetin Chemical Structure
  63. GC48827 Flufenamic Acid-d4

    FFA-d4, Fluphenamic Acid-d4

     An internal standard for the quantification of flufenamic acid Flufenamic Acid-d4 Chemical Structure
  64. GN10727 Forsythoside B Forsythoside B is a phenylethanol glycoside isolated from the leaves of the traditional Chinese medicinal plant Forsythia suspensa. It has multiple biological activities and can be used to treat inflammatory diseases and promote blood circulation Forsythoside B Chemical Structure
  65. GC69131 Frexalimab

    SAR441344; INX-021

    Frexalimab (SAR441344; INX-021) is a monoclonal antibody that targets CD40 ligand (CD40L). Frexalimab has potential for use in multiple sclerosis research.

     Frexalimab Chemical Structure
  66. GC36106 Gamma-glutamylcysteine (TFA)

    γ-Glutamylcysteine TFA

     Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) Chemical Structure
  67. GN10151 Geraniin

    NSC 359346

     Geraniin Chemical Structure
  68. GN10254 Ginsenoside Rc

    NSC 310104, Panaxoside Rc

     Ginsenoside Rc Chemical Structure
  69. GN10538 Ginsenoside Rh1

    20(S)-Ginsenoside Rh1, Prosapogenin A2, Sanchinoside Rh1

     Ginsenoside Rh1 Chemical Structure
  70. GC66345 Golimumab

    CNTO-148

     Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody. Golimumab has anti-inflammation activitity and inhibits IL-6 and IL-1β production. Golimumab acts via targeting and neutralizing TNF to prevent inflammation and destruction of cartilage and bone. Golimumab has the anticancer activity and induces cell apoptosis. Golimumab can be used for rheumatoid arthritis, Crohn's disease and cancer research. Golimumab Chemical Structure
  71. GC15573 GSK481 RIP1(Receptor Interacting Protein Kinase 1) inhibitor GSK481 Chemical Structure
  72. GC18796 Herbicidin A Herbicidin A is an adenine nucleoside antibiotic originally isolated from S. Herbicidin A Chemical Structure
  73. GC31739 Hispidol ((Z)-Hispidol)

    (Z)-Hispidol

     Hispidol ((Z)-Hispidol) ((Z)-Hispidol ((Z)-Hispidol)) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 μM. Hispidol ((Z)-Hispidol) Chemical Structure
  74. GC31692 Homoplantaginin

    Hispidulin-7-O-D-glucoside

     A flavonoid glycoside with antioxidant and anti-inflammatory activities Homoplantaginin Chemical Structure
  75. GC13074 HU 211 NMDA antagonist, novel and non-competitive HU 211 Chemical Structure
  76. GN10217 Hypaconitine Hypaconitine Chemical Structure
  77. GC43894 IKK2 Inhibitor VI

    5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide

    Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling.

     IKK2 Inhibitor VI Chemical Structure
  78. GC74560 Inezetamab Inezetamab is a bispecific anti-CD40 and anti-MSLN IgG1 monoclonal antibody. Inezetamab Chemical Structure
  79. GC19533 Infliximab

    Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.

     Infliximab Chemical Structure
  80. GC74563 Iratumumab

    MDX-060

     Iratumumab (MDX-060) a human anti-CD30 IgG1κ monoclonal antibody. Iratumumab Chemical Structure
  81. GC72419 Iscalimab Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab Chemical Structure
  82. GC64767 ISIS 104838 ISIS?104838?is an antisense oligonucleotide drug that reduces the production of tumor necrosis factor (TNF-alpha),?a substance that contributes to joint pain and swelling in rheumatoid arthritis. ISIS 104838 Chemical Structure
  83. GC70941 ISIS 104838 sodium ISIS 104838 sodium is an antisense oligonucleotide agent that reduces the production of tumor necrosis factor (TNF-alpha), a substance that contributes to joint pain and swelling in rheumatoid arthritis. ISIS 104838 sodium Chemical Structure
  84. GC69304 IW927

    IW927 is an effective small molecule antagonist that can block the binding of TNF-α to TNFRc1, with an IC50 value of 50 nM. It can also disrupt TNF-α-induced IκB phosphorylation, with an IC50 value of 600 nM.

     IW927 Chemical Structure
  85. GC46015 KY 05009 A TNIK inhibitor KY 05009 Chemical Structure
  86. GC47544 Lauric Acid-13C

    Dodecanoic Acid-13C

     An internal standard for the quantification of lauric acid Lauric Acid-13C Chemical Structure
  87. GC62400 LEESGGGLVQPGGSMK acetate LEESGGGLVQPGGSMK acetate, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK acetate Chemical Structure
  88. GC14976 Lenalidomide (CC-5013) An analog of thalidomide Lenalidomide (CC-5013) Chemical Structure
  89. GC13473 Lenalidomide hemihydrate

    TNF-α secretion inhibitor

     Lenalidomide hemihydrate Chemical Structure
  90. GC14015 Lenalidomide hydrochloride

    Revlimid hydrochloride;CC-5013 hydrochloride;CC5013 hydrochloride;CC 5013 hydrochloride

     An analog of thalidomide Lenalidomide hydrochloride Chemical Structure
  91. GC72423 Letolizumab Letolizumab (BMS-986004) is a monoclonal antibody targeting CD40L, which is produced to express mutant IgG1 lacking effector function, including Fc binding and complement fixation. Letolizumab Chemical Structure
  92. GC60225 Licarin A Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Licarin A Chemical Structure
  93. GC74604 Linvoseltamab

    REGN5458

     Linvoseltamab is a bispecific antibody targeting to both BCMA (TNFRSF17) and CD3 epsilon. Linvoseltamab Chemical Structure
  94. GC66382 Lucatumumab

    HCD122

     Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research. Lucatumumab Chemical Structure
  95. GC12045 LY 303511 An inhibitor of cell proliferation LY 303511 Chemical Structure
  96. GC44097 LY303511 (hydrochloride) LY303511 is a close structural analog of LY294002, a selective phosphatidylinositol 3-kinase (PI3K) inhibitor. LY303511 (hydrochloride) Chemical Structure
  97. GC17632 Maslinic Acid

    Crategolic Acid,2α-Hydroxyoleanoic Acid

     Maslinic acid is a pentacyclic triterpene acid widely found in olives and other plants. Maslinic acid has multiple biological activities such as anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, and neuroprotective. Maslinic Acid Chemical Structure
  98. GN10335 Mesaconitine Mesaconitine Chemical Structure
  99. GC48907 Metaxalone-d6

    AHR438-d6; NSC170959-d6

     An internal standard for the quantification of metaxalone Metaxalone-d6 Chemical Structure
  100. GC16007 Methylthiouracil antithyroid preparation Methylthiouracil Chemical Structure
  101. GC74580 Mitazalimab

    ADC-1013; JNJ-64457107

     Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab Chemical Structure

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