VDA
VDAs (vascular disrupting agents) target established tumor vasculature and lead to blood vessels shutdown and selective tumor necrosis.
Products Related to VDA(1)
- GC10235Plinabulin (NPI-2358)CAS: 714272-27-2Purity: >98.00%
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC10235 | Plinabulin (NPI-2358) | 714272-27-2 | >98.00% | |
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells. Plinabulin (NPI-2358) binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells. | ||||