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Angiogenesis

  1. Cat.No. Product Name Information
  2. GC68390 α5β1 integrin agonist-1 α5β1 integrin agonist-1  Chemical Structure
  3. GC68373 BLK-IN-2 BLK-IN-2  Chemical Structure
  4. GC68283 Etrolizumab Etrolizumab  Chemical Structure
  5. GC67940 BTK inhibitor 10 BTK inhibitor 10  Chemical Structure
  6. GC67857 (R)-Elsubrutinib (R)-Elsubrutinib  Chemical Structure
  7. GC67708 PLN-1474 PLN-1474  Chemical Structure
  8. GC65909 Bexotegrast Bexotegrast is a potent inhibitor of αΝβ6 integrin. Bexotegrast can be used for researching fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) (extracted from patent WO2020210404A1, compound 5). Bexotegrast  Chemical Structure
  9. GC65597 Abciximab Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab  Chemical Structure
  10. GC65529 TRAP-6 amide TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide. TRAP-6 amide  Chemical Structure
  11. GC65455 c(phg-isoDGR-(NMe)k) c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM. c(phg-isoDGR-(NMe)k)  Chemical Structure
  12. GC65439 GB-88 GB-88 is an oral, selective non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 ?M. GB-88  Chemical Structure
  13. GC65312 AZ8838 AZ8838 is a potent, competitive, allosteric, orally active non-peptide small molecule antagonist of PAR2 with a pKi of 6.4 for hPAR2. AZ8838  Chemical Structure
  14. GC64979 I-191 I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist. I-191  Chemical Structure
  15. GC64932 αvβ5 integrin-IN-1 αvβ5 integrin-IN-1 is a first potent and selective αvβ5 integrin inhibitor (pIC50 = 8.2) . αvβ5 integrin-IN-1  Chemical Structure
  16. GC64819 Elsubrutinib Elsubrutinib (ABBV-105) is an orally active, potent, selective and irreversible Bruton's tyrosine kinase (BTK) inhibitor。The IC50 of Elsubrutinib for BTK catalytic domain is 0.18 μM. Elsubrutinib  Chemical Structure
  17. GC64571 Sibrafiban Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban  Chemical Structure
  18. GC64360 BTK inhibitor 18 BTK inhibitor 18 is a potent, selective,orally active and covalent Btk inhibitor with a IC50 of 142 nM. BTK inhibitor 18  Chemical Structure
  19. GC64347 Vorapaxar sulfate Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate  Chemical Structure
  20. GC64212 Valategrast hydrochloride Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride  Chemical Structure
  21. GC64120 TAK-020 TAK-020 is a covalent Btk inhibitor, which becomes the clinical candidate. TAK-020  Chemical Structure
  22. GC63896 AS-1763 AS-1763 is a potent, selective, noncovalent, and orally available inhibitor of Bruton’s tyrosine kinase (IC50 = 0.85 nM). AS-1763  Chemical Structure
  23. GC63846 BIIB091 BIIB091 is a highly selective, reversible and orally active BTK inhibitor for treating autoimmune diseases. BIIB091  Chemical Structure
  24. GC63797 (S)-Sunvozertinib (S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK. (S)-Sunvozertinib  Chemical Structure
  25. GC49716 Cyclo(RGDyK) (trifluoroacetate salt) A cyclic peptide ligand of αVβ3 integrin Cyclo(RGDyK) (trifluoroacetate salt)  Chemical Structure
  26. GC49713 SIKVAV (acetate) A laminin α1-derived peptide SIKVAV (acetate)  Chemical Structure
  27. GC49686 N-desmethyl Regorafenib N-oxide An active metabolite of regorafenib N-desmethyl Regorafenib N-oxide  Chemical Structure
  28. GC49562 4-methoxy Estrone An active metabolite of estrone 4-methoxy Estrone  Chemical Structure
  29. GC63658 Atopaxar Atopaxar (E5555) is a potent, orally active, selective and reversible thrombin receptor protease-activated receptor-1 (PAR-1) antagonist. Atopaxar  Chemical Structure
  30. GC63540 SCH79797 SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797  Chemical Structure
  31. GC63490 Valategrast Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast  Chemical Structure
  32. GC63232 Tolebrutinib Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib  Chemical Structure
  33. GC63229 TL-895 TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC50 and a Ki of 1.5 nM and 11.9 nM, respectively. TL-895  Chemical Structure
  34. GC62872 BMS-587101 BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101  Chemical Structure
  35. GC49433 Capsiate A capsaicin analog with diverse biological activities Capsiate  Chemical Structure
  36. GC49358 Sildenafil Chlorosulfonyl An intermediate in the synthesis of sildenafil Sildenafil Chlorosulfonyl  Chemical Structure
  37. GC49349 O-Desethyl Sildenafil A metabolite of sildenafil O-Desethyl Sildenafil  Chemical Structure
  38. GC49221 QLT0267 An ILK inhibitor QLT0267  Chemical Structure
  39. GC62614 SJF620 hydrochloride SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN. SJF620 hydrochloride  Chemical Structure
  40. GC62566 αvβ1 integrin-IN-1 TFA αvβ1 integrin-IN-1 TFA  Chemical Structure
  41. GC62515 Pirtobrutinib Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM. Pirtobrutinib  Chemical Structure
  42. GC62498 BTK inhibitor 17 BTK inhibitor 17 is a potent and orally active irreversible BTK inhibitor with an IC50 of 2.1 nM. BTK inhibitor 17  Chemical Structure
  43. GC62469 Protease-Activated Receptor-1, PAR-1 Agonist TFA Protease-Activated Receptor-1, PAR-1 Agonist TFA is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist TFA corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor. Protease-Activated Receptor-1, PAR-1 Agonist TFA  Chemical Structure
  44. GC62397 RO0270608 RO0270608, the active metabolite of R411, is a dual alpha4beta1-alpha4beta7 (α4β1/α4β7) integrin antagonist. RO0270608  Chemical Structure
  45. GC62380 αvβ1 integrin-IN-1 αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. αvβ1 integrin-IN-1  Chemical Structure
  46. GC62255 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. N-piperidine Ibrutinib hydrochloride  Chemical Structure
  47. GC62182 Echistatin TFA Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin TFA  Chemical Structure
  48. GC62143 Carotegrast methyl Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. Carotegrast methyl  Chemical Structure
  49. GC62101 PAR-2-IN-1 PAR-2-IN-1 is a protease-activated receptor-2 (PAR2) signaling pathway inhibitor with anti-inflammatory and anticancer effects. PAR-2-IN-1  Chemical Structure
  50. GC61777 RWJ-56110 dihydrochloride RWJ-56110 dihydrochloride is a potent, selective, peptide-mimetic inhibitor of PAR-1 activation and internalization (binding IC50=0.44 uM) and shows no effect on PAR-2, PAR-3, or PAR-4. RWJ-56110 dihydrochloride  Chemical Structure
  51. GC61613 Integrin modulator 1 Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1  Chemical Structure
  52. GC61520 Cilengitide TFA Cilengitide is a potent and selective integrin inhibitor for αvβ3 and αvβ5 receptor, with IC50 values of 4 nM and 79 nM, respectively. Cilengitide TFA  Chemical Structure
  53. GC61501 FSLLRY-NH2 TFA FSLLRY-NH2 TFA is a protease-activated receptor 2 (PAR2) inhibitor. FSLLRY-NH2 TFA  Chemical Structure
  54. GC61456 Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a proteinase-activated receptor (PAR-3) agonist peptide. Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA  Chemical Structure
  55. GC48210 TRX-818 (sodium salt) An anticancer compound TRX-818 (sodium salt)  Chemical Structure
  56. GC48195 trans-trismethoxy Resveratrol-d4 An internal standard for the quantification of trans-trismethoxy resveratrol trans-trismethoxy Resveratrol-d4  Chemical Structure
  57. GC48078 Sildenafil-d3 An internal standard for the quantification of sildenafil Sildenafil-d3  Chemical Structure
  58. GC47980 Propionyl-L-carnitine-d3 (chloride) An internal standard for the quantification of propionyl-L-carnitine Propionyl-L-carnitine-d3 (chloride)  Chemical Structure
  59. GC47966 PPACK (trifluoroacetate salt) An antithrombin peptide PPACK (trifluoroacetate salt)  Chemical Structure
  60. GC47965 Pomalidomide-d5 An internal standard for the quantification of pomalidomide Pomalidomide-d5  Chemical Structure
  61. GC47582 Lupulone A beta-acid Lupulone  Chemical Structure
  62. GC47454 IMS 2186 An anti-choroidal neovascularization agent IMS 2186  Chemical Structure
  63. GC47398 Genistein-d4 An internal standard for the quantification of genistein Genistein-d4  Chemical Structure
  64. GC47328 Everolimus-d4 An internal standard for the quantification of everolimus Everolimus-d4  Chemical Structure
  65. GC47234 Diosmetin-d3 An internal standard for the quantification of diosmetin Diosmetin-d3  Chemical Structure
  66. GC47163 D-2-Aminoglutarimide (hydrochloride) A synthetic intermediate D-2-Aminoglutarimide (hydrochloride)  Chemical Structure
  67. GC46899 Axitinib-13C-d3 An internal standard for the quantification of axitinib Axitinib-13C-d3  Chemical Structure
  68. GC46583 3-Amino-2,6-Piperidinedione An active metabolite of (±)-thalidomide 3-Amino-2,6-Piperidinedione  Chemical Structure
  69. GC46474 18-Deoxyherboxidiene A bacterial metabolite with antiangiogenic activity 18-Deoxyherboxidiene  Chemical Structure
  70. GC61323 Tetrac Tetrac (Tetraiodothyroacetic acid), a derivative of L-thyroxine (T4), is a thyrointegrin receptor antagonist. Tetrac blocks the actions of T4 and 3,5,3'-triiodo-L-thyronine (T3) at the cell surface receptor for thyroid hormone on integrin αvβ3. Tetra has anti-angiogenic and anti-tumor activities. Tetrac  Chemical Structure
  71. GC61316 tcY-NH2 TFA tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA  Chemical Structure
  72. GC61109 Natalizumab Natalizumab is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab  Chemical Structure
  73. GC60807 ENMD-1068 hydrochloride Selective protease-activated receptor 2 (PAR2) anatagonist ENMD-1068 hydrochloride  Chemical Structure
  74. GC60551 Acalabrutinib D4 Acalabrutinib D4  Chemical Structure
  75. GC60200 ILK-IN-3 ILK-IN-3 is an integrin linked kinase inhibitor with antitumor activity. ILK-IN-3  Chemical Structure
  76. GC60197 Ibrutinib deacryloylpiperidine Ibrutinib deacryloylpiperidine (IBT4A) is an impurity of Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor with an IC50 of 0.5 nM. Ibrutinib deacryloylpiperidine  Chemical Structure
  77. GC60117 Cyclo(-RGDfK) TFA Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface. Cyclo(-RGDfK) TFA  Chemical Structure
  78. GC60077 BIO5192 hydrate BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate  Chemical Structure
  79. GC50642 LDV α4β1 (VLA-4) ligand LDV  Chemical Structure
  80. GC50325 BOP BOP is a potent and selective dual α9β1/α4β1 integrin inhibitor with Kd values in the picomolar range. BOP  Chemical Structure
  81. GC50078 BIRT 377 Potent negative allosteric modulator of LFA-1 BIRT 377  Chemical Structure
  82. GC50075 BTT 3033 Selective inhibitor of integrin α2β1 BTT 3033  Chemical Structure
  83. GC39194 Ibrutinib D5 Ibrutinib D5 (PCI-32765 D5) is a deuterium labeled Ibrutinib. Ibrutinib is a selective, irreversible Btk inhibitor. Ibrutinib D5  Chemical Structure
  84. GC39146 HIF-1 inhibitor-1 An inhibitor of HIF-1 signaling HIF-1 inhibitor-1  Chemical Structure
  85. GC38893 BMS-688521 BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521  Chemical Structure
  86. GC38873 α2β1 Integrin Ligand Peptide TFA α2β1 Integrin Ligand Peptide TFA  Chemical Structure
  87. GC38801 Irigenin Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells. Irigenin  Chemical Structure
  88. GC38767 Deoxyshikonin A natural products with anti-tumor activity Deoxyshikonin  Chemical Structure
  89. GC38731 2-Furoyl-LIGRLO-amide TFA 2-Furoyl-LIGRLO-amide TFA is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0. 2-Furoyl-LIGRLO-amide TFA  Chemical Structure
  90. GC45880 Cimetidine-d3 An internal standard for the quantification of cimetidine Cimetidine-d3  Chemical Structure
  91. GC45798 Rhein-13C4 An internal standard for the quantification of rhein Rhein-13C4  Chemical Structure
  92. GC45769 Vandetanib-d6 An internal standard for the quantification of vandetanib Vandetanib-d6  Chemical Structure
  93. GC45767 Dovitinib-d8 An internal standard for the quantification of dovitinib Dovitinib-d8  Chemical Structure
  94. GC45688 STX140 An estrogen sulfamate STX140  Chemical Structure
  95. GC38375 Remibrutinib Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib  Chemical Structure
  96. GC38329 GB-110 hydrochloride GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. GB-110 hydrochloride  Chemical Structure
  97. GC38134 Parmodulin 2 Reversible inhibitor of PAR1mediated platelet activation Parmodulin 2  Chemical Structure
  98. GC38128 c(phg-isoD-G-R-(NMe)k) TFA c(phg-isoD-G-R-(NMe)k) TFA  Chemical Structure
  99. GC38044 Fraxinellone Fraxinellone  Chemical Structure
  100. GA23350 PAR-3 (1-6) amide (human) PAR-3 (1-6) amide (human) is a proteinase-activated receptor (PAR-3) agonist peptide. PAR-3 (1-6) amide (human)  Chemical Structure
  101. GA21306 Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) c(RGDyK) has been radioiodinated or modified with chelators for use as radiopharmaceutical. Cyclo(-Arg-Gly-Asp-D-Tyr-Lys)  Chemical Structure

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